MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 329203 | Name: Carumonam Sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Carumonam Sodium, also known as Amasulin and AMA-1080, is a monobactam, penicillin binding protein inhibitor used as antibacterials.

Chemical Structure

Carumonam Sodium
Carumonam Sodium
CAS#86832-68-0 (sodium)

Theoretical Analysis

MedKoo Cat#: 329203

Name: Carumonam Sodium

CAS#: 86832-68-0 (sodium)

Chemical Formula: C12H12N6Na2O10S2

Exact Mass:

Molecular Weight: 510.36

Elemental Analysis: C, 28.24; H, 2.37; N, 16.47; Na, 9.01; O, 31.35; S, 12.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
87638-04-8 (free acid) 86832-68-0 (sodium)
Synonym
Carumonam Sodium; AMA-1080; Ro-17-2301; AMA 1080; Ro 17 2301; AMA1080; Ro172301; Amasulin
IUPAC/Chemical Name
sodium 2-(((1-(2-aminothiazol-4-yl)-2-(((2S,3S)-2-((carbamoyloxy)methyl)-4-oxo-1-sulfonatoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)acetate
InChi Key
BGGXRVPCJUKHTQ-REOVRMSNSA-L
InChi Code
InChI=1S/C12H14N6O10S2.2Na/c13-11-15-4(3-29-11)7(17-28-2-6(19)20)9(21)16-8-5(1-27-12(14)23)18(10(8)22)30(24,25)26;;/h3,5,8H,1-2H2,(H2,13,15)(H2,14,23)(H,16,21)(H,19,20)(H,24,25,26);;/q;2*+1/p-2/b17-7+;;/t5-,8+;;/m1../s1
SMILES Code
O=S(N1[C@H](COC(N)=O)[C@H](NC(C(C2=CSC(N)=N2)=NOCC([O-])=O)=O)C1=O)([O-])=O.[Na+].[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 510.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Srinivas NR. Interspecies scaling of excretory amounts using allometry - retrospective analysis with rifapentine, aztreonam, carumonam, pefloxacin, miloxacin, trovafloxacin, doripenem, imipenem, cefozopran, ceftazidime, linezolid for urinary excretion and rifapentine, cabotegravir, and dolutegravir for fecal excretion. Xenobiotica. 2016 Sep;46(9):784-92. doi: 10.3109/00498254.2015.1121554. PubMed PMID: 26711252. 2: Bulitta JB, Duffull SB, Landersdorfer CB, Kinzig M, Holzgrabe U, Stephan U, Drusano GL, Sörgel F. Comparison of the pharmacokinetics and pharmacodynamic profile of carumonam in cystic fibrosis patients and healthy volunteers. Diagn Microbiol Infect Dis. 2009 Oct;65(2):130-41. doi: 10.1016/j.diagmicrobio.2009.06.018. PubMed PMID: 19748423. 3: Imada A, Kondo M, Okonogi K, Yukishige K, Kuno M. In vitro and in vivo antibacterial activities of carumonam (AMA-1080), a new N-sulfonated monocyclic beta-lactam antibiotic. Antimicrob Agents Chemother. 1985 May;27(5):821-7. PubMed PMID: 3874598; PubMed Central PMCID: PMC180159. 4: Konishi K, Suzuki H, Saruta T, Deguchi N, Fugono T. Pharmacokinetics of carumonam (AMA-1080) in patients with impaired renal function and in those undergoing hemodialysis. Antimicrob Agents Chemother. 1991 Jun;35(6):1048-52. PubMed PMID: 1929242; PubMed Central PMCID: PMC284284. 5: Barclay CA, Iribarren MA, Goldberg M, Traballi CA, Casellas JM. Comparative in vitro activity of carumonam (Ro 17-2301/AMA-1080), a new monobactam, and ceftriaxone against aerobic or facultative gram-negative isolates. Chemotherapy. 1987;33(3):165-71. PubMed PMID: 3595259. 6: Hoepelman AI, Bakker LJ, Verhoef J. Carumonam (Ro 17-2301; AMA-1080) compared with gentamicin for treatment of complicated urinary tract infections. Antimicrob Agents Chemother. 1988 Apr;32(4):473-6. PubMed PMID: 3377459; PubMed Central PMCID: PMC172204. 7: Jones RN, Barry AL, Thornsberry C, Fuchs PC, Packer RR. The anti-microbial activity, beta-lactamase stability, and disk diffusion susceptibility testing of carumonam (RO 17-2301, AMA-1080), a new monobactam. Am J Clin Pathol. 1986 Nov;86(5):608-18. PubMed PMID: 3096130. 8: Le Noc P, Croize J, Le Noc D. [Comparative antibacterial activity of a new monobactam, carumonam (RO 17-2301, AMA 1080) on hospital bacteria resistant to beta lactams]. Pathol Biol (Paris). 1987 May;35(5):451-6. French. PubMed PMID: 3302846. 9: Yoshida K, Mitani M, Naeshiro I, Torii H, Tanayama S. Disposition of carumonam (AMA-1080/Ro 17-2301), a new N-sulfonated monocyclic beta-lactam, in rats and dogs. Antimicrob Agents Chemother. 1986 Jun;29(6):1017-24. PubMed PMID: 3729358; PubMed Central PMCID: PMC180494. 10: Angehrn P. Antibacterial properties of carumonam (Ro 17-2301, AMA-1080), a new sulfonated monocyclic beta-lactam antibiotic. Chemotherapy. 1985;31(6):440-50. PubMed PMID: 3935396. 11: Hohl P, von Graevenitz A, Zollinger-Iten J. In vitro activity of carumonam (Ro 17-2301; AMA-1080) versus enteropathogenic and nonfermentative gram-negative rods and Legionella pneumophila. Antimicrob Agents Chemother. 1988 Oct;32(10):1593-4. PubMed PMID: 3190188; PubMed Central PMCID: PMC175927. 12: Kita Y, Fugono T, Imada A. Comparative pharmacokinetics of carumonam and aztreonam in mice, rats, rabbits, dogs, and cynomolgus monkeys. Antimicrob Agents Chemother. 1986 Jan;29(1):127-34. PubMed PMID: 3729325; PubMed Central PMCID: PMC180377. 13: Matsuda K, Hamana Y, Inoue M, Mitsuhashi S. In-vitro antibacterial activity of AMA-1080. J Antimicrob Chemother. 1985 Nov;16(5):539-47. PubMed PMID: 3878360. 14: Then RL, Kohl I. Affinity of carumonam for penicillin-binding proteins. Chemotherapy. 1985;31(4):246-54. PubMed PMID: 3928279. 15: Weidekamm E, Stoeckel K, Egger HJ, Ziegler WH. Single-dose pharmacokinetics of Ro 17-2301 (AMA-1080), a monocyclic beta-lactam, in humans. Antimicrob Agents Chemother. 1984 Dec;26(6):898-902. PubMed PMID: 6395801; PubMed Central PMCID: PMC180046.

View History

FM1 43

FM1 43

Featured