Synonym
ME-1111; ME 1111; ME1111.
IUPAC/Chemical Name
2-(3,5-dimethyl-1H-pyrazol-1-yl)-5-methylphenol
InChi Key
VQXHPRBERPTLQW-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H14N2O/c1-8-4-5-11(12(15)6-8)14-10(3)7-9(2)13-14/h4-7,15H,1-3H3
SMILES Code
CC1=CC=C(N2N=C(C)C=C2C)C(O)=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
202.26
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hui X, Jung EC, Zhu H, Maibach HI. Antifungal ME1111 in vitro human onychopharmacokinetics. Drug Dev Ind Pharm. 2016 Jul 4:1-8. [Epub ahead of print] PubMed PMID: 27309768.
2: Long L, Hager C, Ghannoum M. Evaluation of the Efficacy of ME1111 in the Topical Treatment of Dermatophytosis in a Guinea Pig Model. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2343-5. doi: 10.1128/AAC.03073-15. Print 2016 Apr. PubMed PMID: 26833160; PubMed Central PMCID: PMC4808162.
3: Gupta AK, Studholme C. Novel investigational therapies for onychomycosis: an update. Expert Opin Investig Drugs. 2016;25(3):297-305. doi: 10.1517/13543784.2016.1142529. Review. PubMed PMID: 26765142.
4: Ghannoum M, Chaturvedi V, Diekema D, Ostrosky-Zeichner L, Rennie R, Walsh T, Wengenack N, Fothergill A, Wiederhold N. Multilaboratory Evaluation of In Vitro Antifungal Susceptibility Testing of Dermatophytes for ME1111. J Clin Microbiol. 2016 Mar;54(3):662-5. doi: 10.1128/JCM.03019-15. Epub 2015 Dec 30. PubMed PMID: 26719434; PubMed Central PMCID: PMC4768001.
5: Tabata Y, Takei-Masuda N, Kubota N, Takahata S, Ohyama M, Kaneda K, Iida M, Maebashi K. Characterization of Antifungal Activity and Nail Penetration of ME1111, a New Antifungal Agent for Topical Treatment of Onychomycosis. Antimicrob Agents Chemother. 2016 Feb;60(2):1035-9. doi: 10.1128/AAC.01739-15. PubMed PMID: 26643333; PubMed Central PMCID: PMC4750676.
6: Takahata S, Kubota N, Takei-Masuda N, Yamada T, Maeda M, Alshahni MM, Abe S, Tabata Y, Maebashi K. Mechanism of Action of ME1111, a Novel Antifungal Agent for Topical Treatment of Onychomycosis. Antimicrob Agents Chemother. 2016 Feb;60(2):873-80. doi: 10.1128/AAC.01790-15. PubMed PMID: 26596944; PubMed Central PMCID: PMC4750688.
7: Ghannoum M, Isham N, Long L. In vitro antifungal activity of ME1111, a new topical agent for onychomycosis, against clinical isolates of dermatophytes. Antimicrob Agents Chemother. 2015 Sep;59(9):5154-8. doi: 10.1128/AAC.00992-15. Epub 2015 Jun 8. PubMed PMID: 26055386; PubMed Central PMCID: PMC4538469.
