Synonym
Clofezone; Perclusone; Clofezonum
IUPAC/Chemical Name
2-(4-chlorophenoxy)-N-(2-(diethylamino)ethyl)acetamide compound with 4-butyl-1,2-diphenylpyrazolidine-3,5-dione (1:1)
InChi Key
ICBCZMIEENEERJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H20N2O2.C14H21ClN2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16;1-3-17(4-2)10-9-16-14(18)11-19-13-7-5-12(15)6-8-13/h4-13,17H,2-3,14H2,1H3;5-8H,3-4,9-11H2,1-2H3,(H,16,18)
SMILES Code
O=C(NCCN(CC)CC)COC1=CC=C(Cl)C=C1.O=C(C2CCCC)N(C3=CC=CC=C3)N(C4=CC=CC=C4)C2=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
593.17
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Brackertz D. Comparison of clofezone and diclofenac in the treatment of out-patients suffering from activated (painful) osteoarthrosis. Z Rheumatol. 1978 Sep-Oct;37(9-10):342-9. PubMed PMID: 153679.
2: Reinicke C, Helbing M, Klingenfeld U, Lasaroff I, Wessel G. [Comparative studies on the bioavailability of various drug forms of phenylbutazone and clofezone (Perclusone)]. Pharmazie. 1984 Dec;39(12):824-7. German. PubMed PMID: 6241720.
3: Celik CM. [Experiences in the management of rheumatoid diseases using different clofezone doses]. Z Rheumatol. 1976 May-Jun;35(5-6):240-7. German. PubMed PMID: 133565.
4: Tamura T. [Clofezone and oxyphenbutazone excluded from dental use]. Nihon Shika Ishikai Zasshi. 1984;37(4):391-5. Japanese. PubMed PMID: 6241218.
5: Keitel W, Weber G, Hoffmann H. [Results of comparative clinical examinations of antirheumatics: clofezone, indomethacin, phenylbutazone]. Schweiz Rundsch Med Prax. 1971 Jan 5;60(1):18-21. German. PubMed PMID: 5313620.
6: David-Chaussé J, David-Chaussé F, Lagoarde J, Picot C. [Therapeutic study of an anti-inflammatory agent, Clofezone]. J Med Bord. 1967 Oct;144(10):1529-35. French. PubMed PMID: 5304355.
7: Stroescu I, Stoicescu M, Dragomir M, Burtea A, Pintea G, Stoia I. [Value of clofezone in the treatment of rheumatic diseases]. Schweiz Rundsch Med Prax. 1971 Feb 16;60(7):217-20. French. PubMed PMID: 5555631.
8: Machtey I. [Short term clofezone therapy in rheumatic diseases]. Harefuah. 1971 Jun 5;80(12):654-6. Hebrew. PubMed PMID: 5156431.
9: Kaiser H. [Clofezone, a new potent antirheumatic drug]. Munch Med Wochenschr. 1973 Dec 7;115(49):2247-8. German. PubMed PMID: 4205416.
10: Ogawa K, Oguchi J, Okada S. [Use of clofezone (pans) in oral surgery]. Shikai Tenbo. 1978;51(2):385-9. Japanese. PubMed PMID: 161230.
11: Vitaus M, Franovic A, Dürrigl T. [Therapeutic use of clofezone in rheumatic diseases]. Schweiz Rundsch Med Prax. 1973 Jan 16;62(3):78-82. German. PubMed PMID: 4282506.
12: Verhaeghe A, Lesage R, Delcambre B. [Clinical trial of a new anti-inflammatory agent in rheumatology, ANP 3260 or clofezone]. Lille Med. 1968 Mar;13(3):Suppl:260-5. French. PubMed PMID: 4927184.
13: Kalbhen DA. The influence of NSAIDs on morphology of articular cartilage. Scand J Rheumatol Suppl. 1988;77:13-22. PubMed PMID: 3238371.
14: Kageyama T. [Clinical result of the treatment of chronic rheumatoid arthritis by non-steroidal anti-inflammatory agent, clofezone. Comparative study with phenylbutazone in a double-blid study at several clinics]. Ryumachi. 1976 Mar;16(1):85-99. Japanese. PubMed PMID: 135360.
15: Rejholec V. [Long-term therapy of rheumatoid arthritis with perclusone]. Z Rechtsmed. 1975 May-Jun;34(5-6):141-8. German. PubMed PMID: 132816.
