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MedKoo Cat#: 328017 | Name: Diperdipine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diperdipine, also known as YS-201, is a calcium channel antagonist potentially for the treatment of angina pectoris and hypertension. Intravenous diperdipine appears to be a potent arteriolar dilating agent that does not affect left ventricular contractility.

Chemical Structure

Diperdipine
Diperdipine
CAS#108852-42-2

Theoretical Analysis

MedKoo Cat#: 328017

Name: Diperdipine

CAS#: 108852-42-2

Chemical Formula: C24H31N3O6

Exact Mass: 457.2213

Molecular Weight: 457.53

Elemental Analysis: C, 63.00; H, 6.83; N, 9.18; O, 20.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Diperdipine; YS-201; YS201; YS 201; Epddnp.
IUPAC/Chemical Name
3-ethyl 5-(2-(piperidin-1-yl)ethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
InChi Key
LBSRZVRITCRLIU-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H31N3O6/c1-4-32-23(28)20-16(2)25-17(3)21(22(20)18-9-8-10-19(15-18)27(30)31)24(29)33-14-13-26-11-6-5-7-12-26/h8-10,15,22,25H,4-7,11-14H2,1-3H3
SMILES Code
O=C(C1=C(C)NC(C)=C(C(OCCN2CCCCC2)=O)C1C3=CC=CC([N+]([O-])=O)=C3)OCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 457.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Herzog R, Leuschner J. Experimental studies on the toxicity of diperdipine following oral and parenteral application. Arzneimittelforschung. 1995 Mar;45(3):240-5. PubMed PMID: 7741776. 2: Marchionni N, Fantini F, Maioli M, Burgisser C, Barletta G, Di Donato M. Synergistic action of postextrasystolic potentiation and diperdipine on left ventricular wall motion abnormalities in coronary heart disease. Am Heart J. 1992 Apr;123(4 Pt 1):977-83. PubMed PMID: 1372461. 3: Di Donato M, Maioli M, Venturi F, Bürgisser C, Fantini F, Biamino G, Marchionni N. Acute hemodynamic effects of intravenous diperdipine, a new dihydropyridine derivative, in coronary heart disease. Am Heart J. 1991 Mar;121(3 Pt 1):776-81. PubMed PMID: 2000744. 4: Greiner PO, Weber S, Angignard J, Berbey B. Evaluation of first pass effect and biliary excretion of diperdipine in the dog. Eur J Drug Metab Pharmacokinet. 1990 Jul-Sep;15(3):185-90. PubMed PMID: 2253647. 5: Greiner PO, Angignard D, Cahn J. High performance liquid chromatography of a new 1,4-dihydropyridine: applications to pharmacokinetic study in dogs. J Pharm Sci. 1988 May;77(5):387-9. PubMed PMID: 3411457.