AGN 201904 is a slowly absorbed, acid-stable pro-proton pump inhibitor (pro-PPI) rapidly converted to omeprazole in the systemic circulation giving a prolonged residence time. AGN-201904 is a proton pump inhibitor; AGN-201904-Z is the sodium salt; AGN-201904 is an omeprazole prodrug. AGN 201904 produced a significantly greater and more prolonged acid suppression than esomeprazole, and nocturnal acid suppression was more prolonged over all 5 days. AGN 201904 should provide true once-a-day treatment and better clinical efficacy than current PPIs.
MedKoo Cat#: 526901
Name: AGN-201904Z
CAS#: 651728-41-5 (sodium)
Chemical Formula: C25H24N3NaO8S2
Exact Mass: 559.1083
Molecular Weight: 581.59
Elemental Analysis: C, 51.63; H, 4.16; N, 7.23; Na, 3.95; O, 22.01; S, 11.02
The following data is based on the product molecular weight 581.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
