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MedKoo Cat#: 328011 | Name: Dopropidil hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dopropidil, also known as CERM-4205; ORG-30701, is a calcium channel antagonist potentially for the treatment of arrhymia and angina pectoris.

Chemical Structure

Dopropidil hydrochloride
Dopropidil hydrochloride
CAS#117241-47-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 328011

Name: Dopropidil hydrochloride

CAS#: 117241-47-1 (HCl)

Chemical Formula: C20H36ClNO2

Exact Mass: 0.0000

Molecular Weight: 357.96

Elemental Analysis: C, 67.11; H, 10.14; Cl, 9.90; N, 3.91; O, 8.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
79700-61-1 (free base) 117241-47-1 (HCl)
Synonym
Dopropidil hydrochloride; CERM-4205; ORG-30701; CERM4205; ORG30701.
IUPAC/Chemical Name
1-(1-isobutoxy-3-((1-(prop-1-yn-1-yl)cyclohexyl)oxy)propan-2-yl)pyrrolidine hydrochloride
InChi Key
PGLZCPBUAJBNEW-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H35NO2.ClH/c1-4-10-20(11-6-5-7-12-20)23-17-19(16-22-15-18(2)3)21-13-8-9-14-21;/h18-19H,5-9,11-17H2,1-3H3;1H
SMILES Code
CC#CC1(OCC(N2CCCC2)COCC(C)C)CCCCC1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS# CAS#117241-47-1 (Dopropidil hydrochloride) CAS#79700-61-1 (Dopropidil free base)

Preparing Stock Solutions

The following data is based on the product molecular weight 357.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bonke FI, Bonke H, Kirchhof CJ. Electrophysiologic effects of ORG 30701 (dopropidil) on rabbit ventricular myocardium. J Cardiovasc Pharmacol. 1993 Feb;21(2):310-5. PubMed PMID: 7679167. 2: Ellory JC, Nash GB, Stone PC, Culliford SJ, Horwitz E, Stuart J. Mode of action and comparative efficacy of pharmacological agents that inhibit calcium-dependent dehydration of sickle cells. Br J Pharmacol. 1992 Aug;106(4):972-7. PubMed PMID: 1393295; PubMed Central PMCID: PMC1907668. 3: Lecocq B, Lecocq V, Prost PL, Fleurot O, Boisson P, Jaillon P. Effects of bepridil and CERM 4205 (ORG 30701) on the relation between cardiac cycle length and QT duration in healthy volunteers. Am J Cardiol. 1990 Sep 1;66(5):636-41. PubMed PMID: 2203243.