AV-101 | CAS#153152-32-0 | NMDA antagonist

MedKoo Cat#: 526891 | Name: AV-101

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AV-101, also known as 4-Chlorokynurenine, is a NMDA glycine B receptor antagonist potentially for treatment of major depressive disorder. AV-101 is an orally active small molecule prodrug candidate that in vivo produces a glycine binding site NMDA receptor antagonist. AV-101 is in clinical development by VistaGen Therapeutics. Inc. as a potential new generation, fast-acting antidepressant, and for other central nervous system (CNS) indications.

Chemical Structure

AV-101

CAS#153152-32-0 (S-isomer)

Theoretical Analysis

MedKoo Cat#: 526891

Name: AV-101

CAS#: 153152-32-0 (S-isomer)

Chemical Formula: C10H11ClN2O3

Exact Mass: 242.0458

Molecular Weight: 242.66

Elemental Analysis: C, 49.50; H, 4.57; Cl, 14.61; N, 11.54; O, 19.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

2369777-80-8 (S-isomer HCl) 153152-32-0 (S-isomer) 75802-84-5 (racemate)

Synonym

AV-101; AV 101; AV101; 4-Cl-KYN; L-4-Cl-KYN; 4ClKYN; L-4ClKYN; 4-Chlorokynurenine;

IUPAC/Chemical Name

(2S)-2-Amino-4-(2-amino-4-chlorophenyl)-4-oxobutanoic acid

InChi Key

HQLHZNDJQSRKDT-QMMMGPOBSA-N

InChi Code

InChI=1S/C10H11ClN2O3/c11-5-1-2-6(7(12)3-5)9(14)4-8(13)10(15)16/h1-3,8H,4,12-13H2,(H,15,16)/t8-/m0/s1

SMILES Code

O=C(O)[C@@H](N)CC(C1=CC=C(Cl)C=C1N)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 242.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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