Synonym
Prodilidine hydrochloride; Prodilidine HCl; A-1981-12; ARC I-O-1; CI 427; CI-427; CL 427; Cogesic; EINECS 223-094-7; NSC 172119.
IUPAC/Chemical Name
1,2-Dimethyl-3-phenyl-3-pyrrolidinol propionate (ester) hydrochloride
InChi Key
RBBBYDOGRKOESS-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H21NO2.ClH/c1-4-14(17)18-15(10-11-16(3)12(15)2)13-8-6-5-7-9-13;/h5-9,12H,4,10-11H2,1-3H3;1H
SMILES Code
CC1N(C)CCC1(OC(CC)=O)C2=CC=CC=C2.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
283.80
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: BOYLE RW, TABET RC, WIGHTMAN BK. ANALGESIC EFFECT OF PRODILIDINE HYDROCHLORIDE (5054) IN ELDERLY PATIENTS WITH CHRONIC PAIN SYNDROME. J Am Geriatr Soc. 1964 Apr;12:379-84. PubMed PMID: 14136816.
2: BATTERMAN RC, MOURATOFF GJ, KAUFMAN JE. PRODILIDINE HYDROCHLORIDE: A NEW MODERATELY POTENT ANALGESIC. Am J Med Sci. 1964 Jan;247:62-8. PubMed PMID: 14106881.
3: KISSEL JW, ALBERT JR, BOXILL GC. The pharmacology of prodilidine hydrochloride, a new analgetic agent. J Pharmacol Exp Ther. 1961 Dec;134:332-40. PubMed PMID: 14456453.
4: SPLITTER SR. Treatment of pain in patients with a new nonnarcotic analgesic, prodilidine hydrochloride (Cogesic). Curr Ther Res Clin Exp. 1961 Nov;3:472-7. PubMed PMID: 13915874.
5: CASS LJ, FREDERIK WS. A new nonnarcotic analgesic, prodilidine hydrochloride. Curr Ther Res Clin Exp. 1961 Mar;3:97-106. PubMed PMID: 13691316. 1: BOYLE RW, TABET RC, WIGHTMAN BK. ANALGESIC EFFECT OF PRODILIDINE HYDROCHLORIDE (5054) IN ELDERLY PATIENTS WITH CHRONIC PAIN SYNDROME. J Am Geriatr Soc. 1964 Apr;12:379-84. PubMed PMID: 14136816.
2: BATTERMAN RC, MOURATOFF GJ, KAUFMAN JE. PRODILIDINE HYDROCHLORIDE: A NEW MODERATELY POTENT ANALGESIC. Am J Med Sci. 1964 Jan;247:62-8. PubMed PMID: 14106881.
3: KISSEL JW, ALBERT JR, BOXILL GC. The pharmacology of prodilidine hydrochloride, a new analgetic agent. J Pharmacol Exp Ther. 1961 Dec;134:332-40. PubMed PMID: 14456453.
4: SPLITTER SR. Treatment of pain in patients with a new nonnarcotic analgesic, prodilidine hydrochloride (Cogesic). Curr Ther Res Clin Exp. 1961 Nov;3:472-7. PubMed PMID: 13915874.
5: CASS LJ, FREDERIK WS. A new nonnarcotic analgesic, prodilidine hydrochloride. Curr Ther Res Clin Exp. 1961 Mar;3:97-106. PubMed PMID: 13691316.