Synonym
Fomepizole; Antizol; Fomepizolum; 4-Methylpyrazole; 4-methyl pyrazole; 4-MP; Fomepizol; NSC-760365; NSC760365; NSC 760365
IUPAC/Chemical Name
4-methyl-1H-pyrazole
InChi Key
RIKMMFOAQPJVMX-UHFFFAOYSA-N
InChi Code
InChI=1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
82.11
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Zakharov S, Pelclova D, Navratil T, Belacek J, Komarc M, Eddleston M, Hovda KE. Fomepizole versus ethanol in the treatment of acute methanol poisoning: Comparison of clinical effectiveness in a mass poisoning outbreak. Clin Toxicol (Phila). 2015;53(8):797-806. doi: 10.3109/15563650.2015.1059946. Epub 2015 Jun 24. PubMed PMID: 26109326.
2: Zakharov S, Navratil T, Pelclova D. Fomepizole in the treatment of acute methanol poisonings: experience from the Czech mass methanol outbreak 2012-2013. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014 Dec;158(4):641-9. doi: 10.5507/bp.2014.056. Epub 2014 Nov 6. PubMed PMID: 25482738.
3: Chen TH, Kuo CH, Huang CT, Wang WL. Use of Fomepizole in Pediatric Methanol Exposure: The First Case Report in Taiwan and a Literature Review. Pediatr Neonatol. 2016 Aug;57(4):351-4. doi: 10.1016/j.pedneo.2013.08.009. Epub 2013 Dec 11. PubMed PMID: 24332660.
4: Maskell KF, Beckett S, Cumpston KL. Methanol Kinetics in Chronic Kidney Disease After Fomepizole: A Case Report. Am J Ther. 2015 Dec 9. [Epub ahead of print] PubMed PMID: 26658806.
5: Endo Y. [Fomepizole]. Chudoku Kenkyu. 2015 Mar;28(1):31-6. Japanese. PubMed PMID: 26399012.
6: Gracia R, Latimer B, McMartin KE. Kinetics of fomepizole in pregnant rats. Clin Toxicol (Phila). 2012 Sep;50(8):743-8. doi: 10.3109/15563650.2012.716518. Epub 2012 Aug 14. PubMed PMID: 22891985.
7: McMartin KE, Sebastian CS, Dies D, Jacobsen D. Kinetics and metabolism of fomepizole in healthy humans. Clin Toxicol (Phila). 2012 Jun;50(5):375-83. doi: 10.3109/15563650.2012.683197. Epub 2012 May 4. PubMed PMID: 22554311.
8: Frémont D, Berleur MP, Mégarbane B. Loading dose of fomepizole is safe in children with presumed toxic alcohol exposure - a case series. Basic Clin Pharmacol Toxicol. 2014 Sep;115(3):229-30. doi: 10.1111/bcpt.12276. Epub 2014 Jun 18. PubMed PMID: 24890990.
9: Rietjens SJ, de Lange DW, Meulenbelt J. Ethylene glycol or methanol intoxication: which antidote should be used, fomepizole or ethanol? Neth J Med. 2014 Feb;72(2):73-9. Review. PubMed PMID: 24659589.
10: Sande M, Thompson D, Monte AA. Fomepizole for severe disulfiram-ethanol reactions. Am J Emerg Med. 2012 Jan;30(1):262.e3-5. doi: 10.1016/j.ajem.2010.11.014. Epub 2011 Jan 3. PubMed PMID: 21208769.
