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MedKoo Cat#: 526051 | Name: Primidolol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Primidolol is a beta adrenergic receptor antagonist. Primidolol is antihypertensive agent.

Chemical Structure

Primidolol
CAS#67227-55-8 (free base)

Theoretical Analysis

MedKoo Cat#: 526051

Name: Primidolol

CAS#: 67227-55-8 (free base)

Chemical Formula: C17H23N3O4

Exact Mass: 333.1689

Molecular Weight: 333.39

Elemental Analysis: C, 61.25; H, 6.95; N, 12.60; O, 19.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
67227-55-8 (free base) 40778-40-3 (HCl)
Synonym
Primidolol; Primidololum; UK-11,443.
IUPAC/Chemical Name
1-(2-((2-Hydroxy-3-(o-tolyloxy)propyl)amino)ethyl)thymine
InChi Key
RETPFDTUCPKFEC-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H23N3O4/c1-12-5-3-4-6-15(12)24-11-14(21)9-18-7-8-20-10-13(2)16(22)19-17(20)23/h3-6,10,14,18,21H,7-9,11H2,1-2H3,(H,19,22,23)
SMILES Code
O=C(N1)N(CCNCC(O)COC2=CC=CC=C2C)C=C(C)C1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 333.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jackson CD, Fishbein L. A toxicological review of beta-adrenergic blockers. Fundam Appl Toxicol. 1986 Apr;6(3):395-422. Review. PubMed PMID: 2870945. 2: Levenson J, Simon AC, Safar ME, Bouthier JD, London GM. Elevation of brachial arterial blood velocity and volumic flow mediated by peripheral beta-adrenoreceptors in patients with borderline hypertension. Circulation. 1985 Apr;71(4):663-8. PubMed PMID: 2982521. 3: Elliott HL, McLean K, Sumner DJ, Meredith PA, Reid JL. Immediate cardiovascular responses to oral prazosin--effects of concurrent beta-blockers. Clin Pharmacol Ther. 1981 Mar;29(3):303-9. PubMed PMID: 6110503. 4: Faccini JM, Irisarri E, Monro AM. A carcinogenicity study in mice of a beta-adrenergic antagonist, primidolol; increased total tumour incidence without tissue specificity. Toxicology. 1981;21(4):279-90. PubMed PMID: 6117955. 5: Saltvedt E, Fauchald P. Effect of single and twice daily doses of primidolol (UK-11,443) in hypertension. Curr Med Res Opin. 1980;6(8):528-33. PubMed PMID: 6104564.

View History

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