Synonym
Halcinonide; Halog; Halcimat; Halcinonida; Halcinonidum; SQ-18566; SQ18566; SQ 18566; NSC-758413; NSC758413; NSC 758413
IUPAC/Chemical Name
(6aS,6bR,7S,8aS,8bS,11aS,12aS,12bS)-8b-(2-chloroacetyl)-6b-fluoro-7-hydroxy-6a,8a,10,10-tetramethyl-1,2,5,6,6a,6b,7,8,8a,8b,11a,12,12a,12b-tetradecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one
InChi Key
MUQNGPZZQDCDFT-DGRLEXMWSA-N
InChi Code
InChI=1S/C24H32ClFO5/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,26)17(28)11-22(16,4)24(19,31-20)18(29)12-25/h9,15-17,19,28H,5-8,10-12H2,1-4H3/t15-,16-,17-,19-,21-,22-,23-,24+/m0/s1
SMILES Code
C[C@@]12[C@@]3(C(CCl)=O)[C@](OC(C)(O3)C)([H])C[C@@]1([H])[C@]4([H])CCC5=CC(CC[C@]5(C)[C@@]4(F)[C@@H](O)C2)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
454.96
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Draelos ZD. Demonstration of the biphasic release of 0.1% halcinonide cream. J Drugs Dermatol. 2015 Jan;14(1):89-90. PubMed PMID: 25607913.
2: Porcu G, Serone E, De Nardis V, Di Giandomenico D, Lucisano G, Scardapane M, Poma A, Ragnini-Wilson A. Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation. PLoS One. 2015 Dec 10;10(12):e0144550. doi: 10.1371/journal.pone.0144550. eCollection 2015. PubMed PMID: 26658258; PubMed Central PMCID: PMC4689554.
3: Draelos ZD. Stratum corneum absorption kinetics of 2 potent topical corticosteroid formulations: a pilot study. Cutis. 2015 Aug;96(2):135-41. PubMed PMID: 26367752.
4: Clijsen R, Baeyens JP, Barel AO, Clarys P. Influence of the timing of ultrasound application on the penetration of corticosteroids. Skin Res Technol. 2013 Feb;19(1):e279-82. doi: 10.1111/j.1600-0846.2012.00639.x. Epub 2012 Jun 20. PubMed PMID: 22712560.
5: Baum EW. Effectiveness and Patient Acceptance of Halcinonide 0.1% Cream in 216g Jars for Large-area Steroid-responsive Dermatoses. J Clin Aesthet Dermatol. 2011 Apr;4(4):29-33. PubMed PMID: 21532875; PubMed Central PMCID: PMC3084610.
6: Bickers DR. A comparative study of amcinonide and halcinonide in the treatment of eczematous dermatitis. Cutis. 1984 Aug;34(2):190-4. PubMed PMID: 6383735.
7: Shi HH, Zhu L, Yang Y, Jin HM, Li RZ, Liang ZQ, Lang JH. [Multicenter randomized clinical study of high-intensity focused ultrasound and cortical hormone in the treatment of non-neoplastic epithelial disorders of vulva]. Zhonghua Yi Xue Za Zhi. 2013 Nov 5;93(41):3291-3. Chinese. PubMed PMID: 24401626.
8: Rauschkolb EW, Bender SH, Ebling JK, McCormick GE, Rosenthal AL. Low concentration halcinonide cream in the topical management of atopic dermatitis in pediatric patients. Cutis. 1981;27(1):105-7. PubMed PMID: 7471802.
9: Zhang YD, Yao W, Wu CX, Chi QM, Zhang JY, Li M. Tropical application of halcinonide cream reduces the severity and incidence of intraperitoneal adhesions in a rat model. Am J Surg. 2002 Jul;184(1):74-77. PubMed PMID: 12152622.
10: Guenther L, Solomon AR, Voorhees JJ. A controlled comparison of amcinonide cream 0.1 percent and halcinonide cream 0.1 percent in the treatment of eczematous dermatitis. Cutis. 1981 Oct;28(4):461-2, 464, 467. PubMed PMID: 7030645.
