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MedKoo Cat#: 328803 | Name: Ibuproxam

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ibuproxam, also known as Ibuproxamum and G-277, is a nonsteroidal antiinflammatory drug (NSAID) used to treat musculoskeletal pain, arthritis, and soft-tissue disorders.

Chemical Structure

Ibuproxam
Ibuproxam
CAS#53648-05-8

Theoretical Analysis

MedKoo Cat#: 328803

Name: Ibuproxam

CAS#: 53648-05-8

Chemical Formula: C13H19NO2

Exact Mass: 221.1416

Molecular Weight: 221.30

Elemental Analysis: C, 70.56; H, 8.65; N, 6.33; O, 14.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ibuproxam; G-277; G-277; G-277; Ibuproxamum
IUPAC/Chemical Name
N-hydroxy-2-(4-isobutylphenyl)propanamide
InChi Key
BYPIURIATSUHDW-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H19NO2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(15)14-16/h4-7,9-10,16H,8H2,1-3H3,(H,14,15)
SMILES Code
O=C(NO)C(C)C1=CC=C(CC(C)C)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 221.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bole-Vunduk B, Verhnjak K, Zmitek J. Anti-inflammatory, analgesic and ulcerogenic properties of S-(+)-ibuproxam, racemic ibuproxam-beta-cyclodextrin and S-(+)-ibuproxam-beta-cyclodextrin. J Pharm Pharmacol. 1996 Nov;48(11):1153-7. PubMed PMID: 8961164. 2: Orzalesi G, Mari F, Bertol E, Selleri R, Pisaturo G. Anti-inflammatory agents: determination of ibuproxam and its metabolite humans. Correlation between bioavailability, tolerance and chemico-physical characteristics. Arzneimittelforschung. 1980;30(9):1607-9. PubMed PMID: 7193032. 3: Mura P, Zerrouk N, Faucci M, Maestrelli F, Chemtob C. Comparative study of ibuproxam complexation with amorphous beta-cyclodextrin derivatives in solution and in the solid state. Eur J Pharm Biopharm. 2002 Sep;54(2):181-91. PubMed PMID: 12191690. 4: Mura P, Faucci MT, Manderioli A, Bramanti G, Ceccarelli L. Compatibility study between ibuproxam and pharmaceutical excipients using differential scanning calorimetry, hot-stage microscopy and scanning electron microscopy. J Pharm Biomed Anal. 1998 Oct;18(1-2):151-63. PubMed PMID: 9863953. 5: Cirri M, Mura P, Rabasco AM, Ginés JM, Moyano JR, Gònzalez-Rodrìguez ML. Characterization of ibuproxam binary and ternary dispersions with hydrophilic carriers. Drug Dev Ind Pharm. 2004 Jan;30(1):65-74. PubMed PMID: 15000431. 6: Ferri S, Di Febo G, Biasco G, Ceroni G, Mariotti S, Muraccini F, Urbani D. [Our experience with the effectiveness and tolerance of ibuproxam in rheumatology]. Minerva Med. 1983 Feb 25;74(7):331-6. Italian. PubMed PMID: 6572296. 7: Mura P, Adragna E, Rabasco AM, Moyano JR, Pérez-Martìnez JI, Arias MJ, Ginés JM. Effects of the host cavity size and the preparation method on the physicochemical properties of ibuproxam-cyclodextrin systems. Drug Dev Ind Pharm. 1999 Mar;25(3):279-87. PubMed PMID: 10071820. 8: Chimichi S, Innocenti F, Orzalesi G. Thermal decomposition of ibuproxam. J Pharm Sci. 1980 May;69(5):521-3. PubMed PMID: 7381734. 9: Orzalesi G, Selleri R, Caldini O, Volpato I, Innocenti F, Colome J, Sacristan A, Varez G. Ibuproxam and ibuprofen. A pharmacological comparison. Arzneimittelforschung. 1977;27(5):1006-12. PubMed PMID: 577862. 10: Orzalesi G, Selleri R, Caldini O, Volpato I, Innocenti F, Colome J, Sacristan A, Varez G, Pisaturo G. Determination of ibuproxam and its metabolites in the plasma and urine of rats. Arzneimittelforschung. 1977;27(5):1012-5. PubMed PMID: 577863.