KAR1123 is an antimalaria agent. KAR1123 cured mice with erythrocytic Plasmodium yoeliiinfection after oral treatment of 25 mg/kg × 4 days or 80 mg/kg × 1 day and also provided partial protection against liver-stage Plasmodium berghei sporozoite-induced infection in mice. Profiling of compound 109 demonstrated a moderately fast in vitroparasite-killing profile. Furthermore, KAR112 displayed excellent potency against both artemisinin-resistant Plasmodium falciparumparasites and Ugandan P. falciparum clinical isolates.
MedKoo Cat#: 128989
Name: KAR1123
CAS#: N/A
Chemical Formula: C20H29N3
Exact Mass: 311.2361
Molecular Weight: 311.47
Elemental Analysis: C, 77.12; H, 9.39; N, 13.49
The following data is based on the product molecular weight 311.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
