Hydroxypropyl-beta-cyclodextrin | HPbCD | CAS#107745-73-3

MedKoo Cat#: 326974 | Name: Hydroxypropyl-beta-cyclodextrin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hydroxypropyl-beta-cyclodextrin, also known as Hydroxypropyl-beta-cyclodextrin; THPB; HP-beta-CD; HPbCD; HP-beta-CyD; VTS-270; HPbetaCD; HPbetaCyD, is a drug candidate potentially for the treatment of Niemann-Pick type C diseases. In April 2009, hydroxypropyl-beta-cyclodextrin (HPbCD) was first approved.

Chemical Structure

Hydroxypropyl-beta-cyclodextrin

CAS#128446-35-5

Theoretical Analysis

MedKoo Cat#: 326974

Name: Hydroxypropyl-beta-cyclodextrin

CAS#: 128446-35-5

Chemical Formula:

Exact Mass: 0.0000

Molecular Weight: 0.00

Elemental Analysis:

Price and Availability

Size	Price	Availability
5g	USD 350.00	2 Weeks
10g	USD 550.00	2 Weeks
25g	USD 950.00	2 Weeks
50g	USD 1,650.00	2 Weeks

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Related CAS #

128446-35-5 107745-73-3

Synonym

Hydroxypropyl-beta-cyclodextri; THPB; HPbCD; HP-beta-CD; HP-beta-CyD; VTS-270; HPbetaCD; HPbetaCyD; 2-hydroxypropyl-β-cyclodextrin; (2-Hydroxypropyl)-β-cyclodextrin

IUPAC/Chemical Name

6A,6B,6C,6D,6E,6F,6G-Heptakis-O-(2-hydroxypropyl)-beta-cyclodextrin

InChi Key

ODLHGICHYURWBS-LKONHMLTSA-N

InChi Code

InChI=1S/C63H112O42/c1-22(64)8-85-15-29-50-36(71)43(78)57(92-29)100-51-30(16-86-9-23(2)65)94-59(45(80)38(51)73)102-53-32(18-88-11-25(4)67)96-61(47(82)40(53)75)104-55-34(20-90-13-27(6)69)98-63(49(84)42(55)77)105-56-35(21-91-14-28(7)70)97-62(48(83)41(56)76)103-54-33(19-89-12-26(5)68)95-60(46(81)39(54)74)101-52-31(17-87-10-24(3)66)93-58(99-50)44(79)37(52)72/h22-84H,8-21H2,1-7H3/t22?,23?,24?,25?,26?,27?,28?,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-/m1/s1

SMILES Code

CC(O)COC[C@H]1O[C@@H]2O[C@@H]3[C@@H](COCC(C)O)O[C@H](O[C@@H]4[C@@H](COCC(C)O)O[C@H](O[C@@H]5[C@@H](COCC(C)O)O[C@H](O[C@@H]6[C@@H](COCC(C)O)O[C@H](O[C@@H]7[C@@H](COCC(C)O)O[C@H](O[C@@H]8[C@@H](COCC(C)O)O[C@H](O[C@H]1[C@H](O)[C@H]2O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

(2-Hydroxypropyl)-beta-cyclodextrin is cyclic polysaccharide comprised of 7 glucopyranose units. This ingredient appears as a solid and functions as a chelating agent. Cyclodextrins are able to form host-guest complexes with hydrophobic molecules and are used in the production cholesterol free products. Beta-cyclodextrin complexes with certain carotenoid food colorants have been shown to intensify color, increase water solubility and improve light stability.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Li X, Yang M, Li Y, Gong W, Wang Y, Shan L, Shao S, Gao C, Zhong W. Formulation and characterization of ternary inclusion complex containing hydroxypropyl-β-cyclodextrin and meglumine for solubility enhancement of poorly water-soluble ST-246, an anti-smallpox drug. Curr Drug Deliv. 2016 Oct 3. PubMed PMID: 27697036. 2: Li P, Song J, Ni X, Guo Q, Wen H, Zhou Q, Shen Y, Huang Y, Qiu P, Lin S, Hu H. Comparison in toxicity and solubilizing capacity of hydroxypropyl-β-cyclodextrin with different degree of substitution. Int J Pharm. 2016 Sep 11;513(1-2):347-356. doi: 10.1016/j.ijpharm.2016.09.036. PubMed PMID: 27628782. 3: Khadka S, El Rassi Z. Postpolymerization modification of a hydroxy monolith precursor. Part III. Activation of poly(hydroxyethyl methacrylate-co-pentaerythritol triacrylate) monolith with epoxy functionalities followed by bonding of glycerol, polyamines, and hydroxypropyl-β-cyclodextrin for hydrophilic interaction and chiral capillary electrochromatography. Electrophoresis. 2016 Sep 9. doi: 10.1002/elps.201600326. PubMed PMID: 27611716. 4: Vartiainen V, Bimbo LM, Hirvonen J, Kauppinen EI, Raula J. Aerosolization, Drug Permeation and Cellular Interaction of Dry Powder Pulmonary Formulations of Corticosteroids with Hydroxypropyl-β-Cyclodextrin as a Solubilizer. Pharm Res. 2016 Sep 7. [Epub ahead of print] PubMed PMID: 27604893. 5: Zhang CL, Liu JC, Yang WB, Chen DL, Jiao ZG. Experimental and molecular docking investigations on the inclusion mechanism of the complex of phloridzin and hydroxypropyl-β-cyclodextrin. Food Chem. 2017 Jan 15;215:124-8. doi: 10.1016/j.foodchem.2016.07.155. Epub 2016 Jul 29. PubMed PMID: 27542458. 6: Huang Y, Zu Y, Zhao X, Wu M, Feng Z, Deng Y, Zu C, Wang L. Preparation of inclusion complex of apigenin-hydroxypropyl-β-cyclodextrin by using supercritical antisolvent process for dissolution and bioavailability enhancement. Int J Pharm. 2016 Sep 25;511(2):921-30. doi: 10.1016/j.ijpharm.2016.08.007. Epub 2016 Aug 8. PubMed PMID: 27515291. 7: Higueras L, López-Carballo G, Gavara R, Hernández-Muñoz P. Effect of hydroxypropyl-β-cyclodextrin and coadjuvants on the sorption capacity of hydrophilic polymer films for monoterpene alcohols. Carbohydr Polym. 2016 Oct 20;151:1193-202. doi: 10.1016/j.carbpol.2016.06.082. Epub 2016 Jun 20. PubMed PMID: 27474670. 8: Qiu C, Gao LN, Yan K, Cui YL, Zhang Y. A promising antitumor activity of evodiamine incorporated in hydroxypropyl-β-cyclodextrin: pro-apoptotic activity in human hepatoma HepG2 cells. Chem Cent J. 2016 Jul 25;10:46. doi: 10.1186/s13065-016-0191-y. eCollection 2016. PubMed PMID: 27458481; PubMed Central PMCID: PMC4959055. 9: Madrid F, Rubio-Bellido M, Villaverde J, Tejada M, Morillo E. Natural attenuation of fluorene and pyrene in contaminated soils and assisted with hydroxypropyl-β-cyclodextrin. Effect of co-contamination. Sci Total Environ. 2016 Nov 15;571:42-9. doi: 10.1016/j.scitotenv.2016.07.110. Epub 2016 Jul 23. PubMed PMID: 27454573. 10: Sugita M, Hirata F. Predicting the binding free energy of the inclusion process of 2-hydroxypropyl-β-cyclodextrin and small molecules by means of the MM/3D-RISM method. J Phys Condens Matter. 2016 Sep 28;28(38):384002. doi: 10.1088/0953-8984/28/38/384002. Epub 2016 Jul 25. PubMed PMID: 27452185. 11: Tang P, Tang B, Wang Q, Xu K, Xiong X, Li H. Effect of hydroxypropyl-β-cyclodextrin on the bounding of salazosulfapyridine to human serum albumin. Int J Biol Macromol. 2016 Nov;92:105-115. doi: 10.1016/j.ijbiomac.2016.07.033. PubMed PMID: 27418290. 12: Kellici TF, Chatziathanasiadou MV, Diamantis D, Chatzikonstantinou AV, Andreadelis I, Christodoulou E, Valsami G, Mavromoustakos T, Tzakos AG. Mapping the interactions and bioactivity of quercetin-(2-hydroxypropyl)-β-cyclodextrin complex. Int J Pharm. 2016 Sep 10;511(1):303-11. doi: 10.1016/j.ijpharm.2016.07.008. Epub 2016 Jul 7. PubMed PMID: 27395802. 13: Zhang Y, Yang X, Gu C, Wang F, Bian Y, Song Y, Wang D, Jiang X. A novel bioaccessibility prediction method for PAHs in soil: Composite extraction with hydroxypropyl-β-cyclodextrin and extracellular polymer substances. Sci Total Environ. 2016 Nov 1;569-570:997-1003. doi: 10.1016/j.scitotenv.2016.05.226. Epub 2016 Jul 6. PubMed PMID: 27395072. 14: Yalcin A, Soddu E, Turunc Bayrakdar E, Uyanikgil Y, Kanit L, Armagan G, Rassu G, Gavini E, Giunchedi P. Neuroprotective Effects of Engineered Polymeric Nasal Microspheres Containing Hydroxypropyl-β-cyclodextrin on β-Amyloid (1-42)-Induced Toxicity. J Pharm Sci. 2016 Aug;105(8):2372-80. doi: 10.1016/j.xphs.2016.05.017. Epub 2016 Jun 25. PubMed PMID: 27353207. 15: Iohara D, Umezaki Y, Anraku M, Uekama K, Hirayama F. In Vitro and In Vivo Evaluation of Hydrophilic C60(OH)10/2-Hydroxypropyl-β-cyclodextrin Nanoparticles as an Antioxidant. J Pharm Sci. 2016 Sep;105(9):2959-65. doi: 10.1016/j.xphs.2016.04.033. Epub 2016 Jun 14. PubMed PMID: 27317367. 16: García-Robles AA, Company-Albir MJ, Megías-Vericat JE, Fernández-Megía MJ, Pérez-Miralles FC, López-Briz E, Alcalá-Vicente C, Galeano I, Casanova B, Poveda JL. Use of 2 hydroxypropyl-beta-cyclodextrin therapy in two adult Niemann Pick Type C patients. J Neurol Sci. 2016 Jul 15;366:65-7. doi: 10.1016/j.jns.2016.04.048. Epub 2016 Apr 26. PubMed PMID: 27288778. 17: Sun Y, Jia L, Zhou H, Mao M, Wang X, Wei L, Sun L. Pharmacokinetics of 16-dehydropregnenolone hydroxypropyl-β-cyclodextrin inclusion complex following peroral administration. Pharm Dev Technol. 2016 Jun 7:1-11. [Epub ahead of print] PubMed PMID: 27269370. 18: Fumić B, Končić MZ, Jug M. Therapeutic Potential of Hydroxypropyl-β-Cyclodextrin-Based Extract of Medicago sativa in the Treatment of Mucopolysaccharidoses. Planta Med. 2016 May 24. [Epub ahead of print] PubMed PMID: 27220073. 19: Chiu KW, Robson S, Devi JL, Woodward A, Whittem T. The cardiopulmonary effects and quality of anesthesia after induction with alfaxalone in 2-hydroxypropyl-β-cyclodextrin in dogs and cats: a systematic review. J Vet Pharmacol Ther. 2016 May 18. doi: 10.1111/jvp.12312. [Epub ahead of print] Review. PubMed PMID: 27188881. 20: Gan TJ, Singla N, Daniels SE, Lacouture PG, Min LH, Reyes CR, Carr DB. Cardiovascular safety of hydroxypropyl-β-cyclodextrin-diclofenac in the management of acute postsurgical pain: a pooled analysis of 2 randomized, double-blind, placebo- and active comparator-controlled phase III clinical trials. J Clin Anesth. 2016 Jun;31:249-58. doi: 10.1016/j.jclinane.2016.01.020. Epub 2016 Apr 16. PubMed PMID: 27185721.