Indisetron Dihydrochloride | N-3389T | CAS#160472-97-9 | CAS#141549-75-9 | 5HT3 & 5HT4 Receptor Antagonist

MedKoo Cat#: 328716 | Name: Indisetron Dihydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Indisetron Dihydrochloride, also known as N-3389T and Sinseron, is a 5-HT(3) and 5-HT(4) receptor antagonist. Indisetron reduces 2-methyl-5-serotonin (HT)-induced bradycardia. The 5-HT3 antagonistic activity is over 20 times more than that of granisetron or ondansetron, indicating the excellent anti-emetic activity against anticancer drug induced vomiting.

Chemical Structure

Indisetron Dihydrochloride

CAS#160472-97-9 (2HCl)

Theoretical Analysis

MedKoo Cat#: 328716

Name: Indisetron Dihydrochloride

CAS#: 160472-97-9 (2HCl)

Chemical Formula: C17H25Cl2N5O

Exact Mass:

Molecular Weight: 386.32

Elemental Analysis: C, 52.85; H, 6.52; Cl, 18.35; N, 18.13; O, 4.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

160472-97-9 (2HCl) 141549-75-9 (free base)

Synonym

Indisetron Dihydrochloride; N-3389T; N 3389T; N3389T; Sinseron

IUPAC/Chemical Name

N-(3,9-dimethyl-3,9-diazabicyclo[3.3.1]nonan-7-yl)-1H-indazole-3-carboxamide dihydrochloride

InChi Key

KOYCUQMOCJHRJC-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H23N5O.2ClH/c1-21-9-12-7-11(8-13(10-21)22(12)2)18-17(23)16-14-5-3-4-6-15(14)19-20-16;;/h3-6,11-13H,7-10H2,1-2H3,(H,18,23)(H,19,20);2*1H

SMILES Code

O=C(C1=NNC2=C1C=CC=C2)NC3CC4CN(C)CC(N4C)C3.[H]Cl.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS# 141549-75-9(Indisetron ) 160472-97-9(Indisetron 2HCl)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 386.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Tsukagoshi S; Tokyo Cooperative Oncology Group. [Introduction of novel anti-emetic agent, indisetron hydrochloride, developed recently in Japan]. Gan To Kagaku Ryoho. 2005 Apr;32(4):567-73. Review. Japanese. PubMed PMID: 15853230. 2: Iritani E, Isono K, Izumo T, Takeda N, Kanemura T, Tamaoki J, Nagai A. [The efficacy of indisetron hydrochloride for the management of chemotherapy-induced nausea and vomiting for lung cancer]. Gan To Kagaku Ryoho. 2009 Sep;36(9):1489-92. Japanese. PubMed PMID: 19755818. 3: Kanbe M, Osada M. [CPT-11-induced diarrhea treated with indisetron hydrochloride--a case report]. Gan To Kagaku Ryoho. 2005 Dec;32(13):2145-7. Japanese. PubMed PMID: 16352947. 4: Nakatsumi H, Komatsu Y, Yuki S, Sogabe S, Tateyama M, Muto S, Kudo M, Kato K, Miyagishima T, Uebayashi M, Meguro T, Oba K, Asaka M. Optimal dose period for indisetron tablets for preventing chemotherapy-induced nausea and vomiting with modified FOLFOX6: a randomized pilot study. Chemotherapy. 2012;58(6):439-44. doi: 10.1159/000345920. Epub 2013 Jan 29. PubMed PMID: 23364217. 5: Sharma A, Sonah H, Deshmukh RK, Gupta NK, Singh NK, Sharma TR. Analysis of genetic diversity in earthworms using DNA markers. Zoolog Sci. 2011 Jan;28(1):25-31. doi: 10.2108/zsj.28.25. PubMed PMID: 21186943.