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MedKoo Cat#: 328710 | Name: Isoflurane
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isoflurane, also known as Forane and Terrell, is a stable, non-explosive inhalation anesthetic, that has been reported to induce caspase-3 activation.

Chemical Structure

Isoflurane
Isoflurane
CAS#26675-46-7

Theoretical Analysis

MedKoo Cat#: 328710

Name: Isoflurane

CAS#: 26675-46-7

Chemical Formula: C3H2ClF5O

Exact Mass: 183.9714

Molecular Weight: 184.49

Elemental Analysis: C, 19.53; H, 1.09; Cl, 19.22; F, 51.49; O, 8.67

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
5g USD 450.00 2 Weeks
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Related CAS #
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Synonym
Isoflurane; HSDB 8057; HSDB-8057; HSDB8057; Forane; Terrell;
IUPAC/Chemical Name
2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane
InChi Key
PIWKPBJCKXDKJR-UHFFFAOYSA-N
InChi Code
InChI=1S/C3H2ClF5O/c4-1(3(7,8)9)10-2(5)6/h1-2H
SMILES Code
FC(OC(Cl)C(F)(F)F)F
Appearance
Liquid
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 184.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Olutoye OA, Sheikh F, Zamora IJ, Yu L, Akinkuotu AC, Adesina AM, Olutoye OO. Repeated isoflurane exposure and neuroapoptosis in the midgestation fetal sheep brain. Am J Obstet Gynecol. 2016 Apr;214(4):542.e1-8. doi: 10.1016/j.ajog.2015.10.927. Epub 2015 Nov 4. PubMed PMID: 26546852. 2: Chang PS, Walker SM, Fitzgerald M. Differential Suppression of Spontaneous and Noxious-evoked Somatosensory Cortical Activity by Isoflurane in the Neonatal Rat. Anesthesiology. 2016 Apr;124(4):885-98. doi: 10.1097/ALN.0000000000001017. PubMed PMID: 26808637. 3: Lv P, Xiao Y, Liu B, Wang Y, Zhang X, Sun H, Li F, Yao L, Zhang W, Liu L, Gao X, Wu M, Tang Y, Chen Q, Gong Q, Lui S. Dose-dependent effects of isoflurane on regional activity and neural network function: A resting-state fMRI study of 14 rhesus monkeys: An observational study. Neurosci Lett. 2016 Jan 12;611:116-22. doi: 10.1016/j.neulet.2015.11.037. Epub 2015 Nov 26. PubMed PMID: 26633103. 4: Recio-Pinto E, Montoya-Gacharna JV, Xu F, Blanck TJ. Isoflurane, but Not the Nonimmobilizers F6 and F8, Inhibits Rat Spinal Cord Motor Neuron CaV1 Calcium Currents. Anesth Analg. 2016 Mar;122(3):730-7. doi: 10.1213/ANE.0000000000001111. PubMed PMID: 26702867; PubMed Central PMCID: PMC4760920. 5: Johansen SL, Iceman KE, Iceman CR, Taylor BE, Harris MB. Isoflurane causes concentration-dependent inhibition of medullary raphé 5-HT neurons in situ. Auton Neurosci. 2015 Dec;193:51-6. doi: 10.1016/j.autneu.2015.07.002. Epub 2015 Jul 17. PubMed PMID: 26213357; PubMed Central PMCID: PMC4658272. 6: Cheng B, Zhang Y, Wang A, Dong Y, Xie Z. Vitamin C Attenuates Isoflurane-Induced Caspase-3 Activation and Cognitive Impairment. Mol Neurobiol. 2015 Dec;52(3):1580-9. doi: 10.1007/s12035-014-8959-3. Epub 2014 Nov 4. PubMed PMID: 25367886; PubMed Central PMCID: PMC4418956. 7: Chen X, Wang W, Zhang J, Li S, Zhao Y, Tan L, Luo A. Involvement of caspase-3/PTEN signaling pathway in isoflurane-induced decrease of self-renewal capacity of hippocampal neural precursor cells. Brain Res. 2015 Nov 2;1625:275-86. doi: 10.1016/j.brainres.2015.08.047. Epub 2015 Sep 11. PubMed PMID: 26367448. 8: Ge HW, Hu WW, Ma LL, Kong FJ. Endoplasmic reticulum stress pathway mediates isoflurane-induced neuroapoptosis and cognitive impairments in aged rats. Physiol Behav. 2015 Nov 1;151:16-23. doi: 10.1016/j.physbeh.2015.07.008. Epub 2015 Jul 8. PubMed PMID: 26162760. 9: Bellgardt M, Bomberg H, Herzog-Niescery J, Dasch B, Vogelsang H, Weber TP, Steinfort C, Uhl W, Wagenpfeil S, Volk T, Meiser A. Survival after long-term isoflurane sedation as opposed to intravenous sedation in critically ill surgical patients: Retrospective analysis. Eur J Anaesthesiol. 2016 Jan;33(1):6-13. doi: 10.1097/EJA.0000000000000252. PubMed PMID: 25793760. 10: Escobar A, da Rocha RW, Pypendop BH, Zangirolami Filho D, Sousa SS, Valadão CA. Effects of Methadone on the Minimum Anesthetic Concentration of Isoflurane, and Its Effects on Heart Rate, Blood Pressure and Ventilation during Isoflurane Anesthesia in Hens (Gallus gallus domesticus). PLoS One. 2016 Mar 28;11(3):e0152546. doi: 10.1371/journal.pone.0152546. eCollection 2016. PubMed PMID: 27018890; PubMed Central PMCID: PMC4809615. 11: Wang S, Zhuang L, Yang X, Li Q, Xue Q, Luo Y, Zhang F, Yu B. Impaired acquisition of conditioned taste aversion memory induced by isoflurane is accompanied with calcineurin activation and Egr-1 down-regulation in amygdala in rats. Neurosci Lett. 2015 Oct 21;607:114-9. doi: 10.1016/j.neulet.2015.09.022. Epub 2015 Sep 21. PubMed PMID: 26393333. 12: Cheng Y, Mitchell-Flack MJ, Wang A, Levy RJ. Carbon monoxide modulates cytochrome oxidase activity and oxidative stress in the developing murine brain during isoflurane exposure. Free Radic Biol Med. 2015 Sep;86:191-9. doi: 10.1016/j.freeradbiomed.2015.05.029. Epub 2015 May 29. PubMed PMID: 26032170; PubMed Central PMCID: PMC4568063. 13: Hou L, Liu T, Wang J. Isoflurane suppresses the self-renewal of normal mouse neural stem cells in a p53-dependent manner by activating the Lkb1-p53-p21 signalling pathway. Mol Med Rep. 2015 Nov;12(5):7412-8. doi: 10.3892/mmr.2015.4387. Epub 2015 Sep 29. PubMed PMID: 26459766; PubMed Central PMCID: PMC4626134. 14: Noda T, Takahashi H. Anesthetic effects of isoflurane on the tonotopic map and neuronal population activity in the rat auditory cortex. Eur J Neurosci. 2015 Sep;42(6):2298-311. doi: 10.1111/ejn.13007. Epub 2015 Jul 23. PubMed PMID: 26118739. 15: Floriano BP, Wagatsuma JT, Ferreira JZ, Abimussi CJ, Menegheti TM, Santos PS, Oliva VN. Effects on indicators of tissue perfusion in dogs anesthetized with isoflurane at two multiples of the minimum alveolar concentration. Am J Vet Res. 2016 Jan;77(1):24-31. doi: 10.2460/ajvr.77.1.24. PubMed PMID: 26709933.