Isoguvacine is a GABAA receptor agonist. It binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit-contanining GABAA receptors in a FLIPR assay. It inhibits CA1 population spikes in rat hippocampal slices and high potassium/low magnesium-induced seizures in rat pups. Chronic administration of isoguvacine improves tactile over-reactivity, anxiety-like behaviors, and social impairments in mouse models of autism spectrum disorder (ASD).
MedKoo Cat#: 463976
Name: Isoguvacine HCl
CAS#: 68547-97-7
Chemical Formula: C6H10ClNO2
Exact Mass: 163.0400
Molecular Weight: 163.60
Elemental Analysis: C, 44.05; H, 6.16; Cl, 21.67; N, 8.56; O, 19.56
The following data is based on the product molecular weight 163.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
