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MedKoo Cat#: 328612 | Name: Meprednisone
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Meprednisone, also known as NSC-63278 and Betapar, is a glucocorticoid receptor agonist used to treat allergic and inflammatory of the eye.

Chemical Structure

Meprednisone
Meprednisone
CAS#1247-42-3

Theoretical Analysis

MedKoo Cat#: 328612

Name: Meprednisone

CAS#: 1247-42-3

Chemical Formula: C22H28O5

Exact Mass: 372.1937

Molecular Weight: 372.46

Elemental Analysis: C, 70.94; H, 7.58; O, 21.48

Price and Availability

Size Price Availability Quantity
25mg USD 350.00 2 weeks
100mg USD 750.00 2 weeks
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Related CAS #
No Data
Synonym
Meprednisone; NSC-63278; NSC 63278; NSC63278; Betapar; Medrysone
IUPAC/Chemical Name
(8S,9S,10R,13S,14S,16S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthrene-3,11(6H)-dione
InChi Key
PIDANAQULIKBQS-RNUIGHNZSA-N
InChi Code
InChI=1S/C22H28O5/c1-12-8-16-15-5-4-13-9-14(24)6-7-20(13,2)19(15)17(25)10-21(16,3)22(12,27)18(26)11-23/h6-7,9,12,15-16,19,23,27H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,19+,20-,21-,22-/m0/s1
SMILES Code
O=C(C=C1CC[C@@]2([H])[C@]3([H])C[C@H](C)[C@@](O)([C@]3(C4)C)C(CO)=O)C=C[C@]1(C)[C@@]2([H])C4=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Meprednisone is a glucocorticoid and a methylated derivative of prednisone.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
DMF 30.0 80.55
DMSO 68.3 183.46
DMSO:PBS (pH 7.2) (1:5) 0.1 0.27
Ethanol 7.0 18.79
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 372.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Ma X, He J, Yan J, Wang Q, Li H. Comparative analysis the binding affinity of mycophenolic sodium and meprednisone with human serum albumin: Insight by NMR relaxation data and docking simulation. Chem Biol Interact. 2016 Mar 25;248:52-9. doi: 10.1016/j.cbi.2016.02.009. Epub 2016 Feb 16. PubMed PMID: 26892221. 2: Fernández D, Vega D, Ellena JA. 17alpha,21-Dihydroxy-16beta-methylpregna-1,4-diene-3,11,20-trione (meprednisone). Acta Crystallogr C. 2003 Apr;59(Pt 4):O187-9. Epub 2003 Mar 11. PubMed PMID: 12682403. 3: Meprednisone (betapar). Med Lett Drugs Ther. 1971 Dec 24;13(26):106-7. PubMed PMID: 5163919. 4: Mendizabal M, Marciano S, Videla MG, Anders M, Zerega A, Balderramo DC, Tisi Baña MR, Barrabino M, Gil O, Mastai R, Yantorno S, Gadano A, Silva MO. Fulminant presentation of autoimmune hepatitis: clinical features and early predictors of corticosteroid treatment failure. Eur J Gastroenterol Hepatol. 2015 Jun;27(6):644-8. doi: 10.1097/MEG.0000000000000353. PubMed PMID: 25923939. 5: Fraire ME, Sanchez-Vallecillo MV, Zernotti ME, Paoletti OA. Effect of premedication with systemic steroids on surgical field bleeding and visibility during nasosinusal endoscopic surgery. Acta Otorrinolaringol Esp. 2013 Mar-Apr;64(2):133-9. doi: 10.1016/j.otorri.2012.09.009. Epub 2013 Jan 11. English, Spanish. PubMed PMID: 23317561. 6: Pisoni CN, Ibañez S, Guevara M, Castro D, Romero Vidomlansky S. Granulomatosis with polyangiitis: recurrence presenting as ependimoplexitis. Clin Exp Rheumatol. 2014 May-Jun;32(3 Suppl 82):S70-2. Epub 2014 Mar 17. PubMed PMID: 24642347. 7: Vinicki JP, Catalan Pellet S, Pappalardo C, Cruzat VC, Spinetto MA, Dubinsky D, Tiraboschi IN, Laborde HA, Nasswetter G. Invasive fungal infections in Argentine patients with systemic lupus erythematosus. Lupus. 2013 Aug;22(9):892-8. doi: 10.1177/0961203313496342. Epub 2013 Jul 16. PubMed PMID: 23861029. 8: Trimarchi H, Karl A, Raña MS, Forrester M, Pomeranz V, Lombi F, Iotti A. Initially Nondiagnosed Fabry's Disease when Electron Microscopy Is Lacking: The Continuing Story of Focal and Segmental Glomerulosclerosis. Case Rep Nephrol Urol. 2013 May 4;3(1):51-7. doi: 10.1159/000351516. eCollection 2013. PubMed PMID: 24167512; PubMed Central PMCID: PMC3808792. 9: Millar K, Manlhiot C, Yeung RS, Somji Z, McCrindle BW. Corticosteroid administration for patients with coronary artery aneurysms after Kawasaki disease may be associated with impaired regression. Int J Cardiol. 2012 Jan 12;154(1):9-13. doi: 10.1016/j.ijcard.2010.08.070. Epub 2010 Sep 20. PubMed PMID: 20851480. 10: Testa ME, Maffey A, Colom A, Agüero L, Rogé I, Andrewartha MS, Teper A. [Pulmonary hemorrhage associated with celiac disease]. Arch Argent Pediatr. 2012 Aug;110(4):e72-6. doi: 10.1590/S0325-00752012000400016. Spanish. PubMed PMID: 22859336. 11: Alvarez PA, Egozcue J, Sleiman J, Moretti L, Di Girolamo G, Keller GA. Severe neutropenia in a renal transplant patient suggesting an interaction between mycophenolate and fenofibrate. Curr Drug Saf. 2012 Feb;7(1):24-9. PubMed PMID: 22663953. 12: Frider B, Bruno A, Zylberman M, Oría A, Amante M. Autoimmune cholangitis associated to IgG4 related sclerosing disease. Acta Gastroenterol Latinoam. 2011 Mar;41(1):55-9. PubMed PMID: 21534331. 13: Hendel I, Mastrapascua S, Martínez C, Martínez F, Escobar O. [Fulminating sclerosant peritonitis. Spectacular response to treatment with steroids]. Nefrologia. 2010;30(1):135-6. doi: 10.3265/Nefrologia.pre2010.Jan.10222. Spanish. PubMed PMID: 20098480. 14: Schmutz JL, Barbaud A, Trechot P. [Drug-induced lichenoid eruptions]. Ann Dermatol Venereol. 2006 Apr;133(4):409. French. PubMed PMID: 16733466. 15: Korula J. Tuberculous peritonitis complicating corticosteroid therapy for acute alcoholic hepatitis. Dig Dis Sci. 1995 Oct;40(10):2119-20. PubMed PMID: 7587777.