MedKoo Cat#: 111510 | Name: Poldine Methylsulfate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Poldine methylsulfate, or Nacton, is a biochemical used for gastrointestinal disorders.

Chemical Structure

Poldine Methylsulfate
Poldine Methylsulfate
CAS#545-80-2

Theoretical Analysis

MedKoo Cat#: 111510

Name: Poldine Methylsulfate

CAS#: 545-80-2

Chemical Formula: C22H29NO7S

Exact Mass: 451.1700

Molecular Weight: 451.53

Elemental Analysis: C, 58.52; H, 6.47; N, 3.10; O, 24.80; S, 7.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Poldine metilsulfate; I.S. 499; IS499; IS 499; Nacton;
IUPAC/Chemical Name
2-((2-hydroxy-2,2-diphenylacetoxy)methyl)-1,1-dimethylpyrrolidin-1-ium methyl sulfate
InChi Key
DQHAZEKGLAMVFA-UHFFFAOYSA-M
InChi Code
InChI=1S/C21H26NO3.CH4O4S/c1-22(2)15-9-14-19(22)16-25-20(23)21(24,17-10-5-3-6-11-17)18-12-7-4-8-13-18;1-5-6(2,3)4/h3-8,10-13,19,24H,9,14-16H2,1-2H3;1H3,(H,2,3,4)/q+1;/p-1
SMILES Code
C[N+]1(CCCC1COC(C(C2=CC=CC=C2)(O)C3=CC=CC=C3)=O)C.COS([O-])(=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 451.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hainer V, Zák A, Bakos K, Wernischová V, Bĕlikovová H. Vliv cholinergní blokády Nactonem na sekreci inzulínu u obézních pacientů [Nacton-induced cholinergic block and its effect on insulin secretion in obese patients]. Cas Lek Cesk. 1982 Jul;121(27):844-7. Czech. PMID: 6749290. 2: Heathcote BV, Parry M. Pirenzepine selectively inhibits gastric acid secretion: a comparative pharmacological study between pirenzepine and seven other antiacetylcholine drugs. Scand J Gastroenterol Suppl. 1980;66:15-26. PMID: 6113681. 3: CASTROLDE P, DE ALMEIDA N Jr, DE REZENDE HP. EFEITO DO METILSULFATO DE POLDINA (NACTON) S OBRE A SECRE C AO G'ASTRICA BASAL E AP'OS A ESTIMULA C AO PELO HISTALOG [EFFECT OF POLDINE METHYLSULFATE (NACTON) ON GASTRIC SECRETION, BASAL AND FOLLOWING HISTALOG STIMULATION]. Hospital (Rio J). 1964 Mar;65:583-90. Portuguese. PMID: 14140068. 4: POOLE JW, MONTE AA. SPECTROPHOTOMETRIC DETERMINATION OF POLDINE METHYLSULFATE AND APPLICATION TO PHARMACEUTICAL PREPARATIONS. J Pharm Sci. 1964 Feb;53:158-61. doi: 10.1002/jps.2600530210. PMID: 14123955. 5: ROACH TC. Therapy of peptic ulcer. A double blind comparison of poldine methylsulfate with butabarbital sodium and propantheline bromide with phenobarbital. J La State Med Soc. 1963 Apr;115:136-9. PMID: 13974190. 6: VASCONCELLOS D, CORDEIRO F, FONSECA JA, de MELO. [Effect of "Nacton" on patients with duodenal ulcer]. Hospital (Rio J). 1962 Dec;62:1315-20. Portuguese. PMID: 13996382. 7: WILSON R, LONG C. Nacton and milk treatment of duodenal ulcer. J Ir Med Assoc. 1960 Nov;47:117-9. PMID: 13785700. 8: TRIVELLATO E, MURARI G. [Activity of IS-499 (nacton) on gastric secretion in the rat]. Boll Chim Farm. 1960 Feb;99:84-7. Italian. PMID: 13839420. 9: DOUTHWAITE AH, HUNT JN. Effect of nacton in patients with duodenal ulcer. Br Med J. 1958 May 3;1(5078):1030-4. doi: 10.1136/bmj.1.5078.1030. PMID: 13536410; PMCID: PMC2028628.