AZD-3289 | CAS#1227163-49-6 | BACE1 inhibitor

MedKoo Cat#: 526977 | Name: AZD-3289

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZD-3289 is a potent BACE1 inhibitor potentially for the treatment of Alzheimer's disease.

Chemical Structure

AZD-3289

CAS#1227163-49-6

Theoretical Analysis

MedKoo Cat#: 526977

Name: AZD-3289

CAS#: 1227163-49-6

Chemical Formula: C24H17F4N5

Exact Mass: 451.1420

Molecular Weight: 451.43

Elemental Analysis: C, 63.86; H, 3.80; F, 16.83; N, 15.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

AZD-3289; AZD 3289; AZD3289.

IUPAC/Chemical Name

(3S)-7-fluoro-3-(3-(pyrimidin-5-yl)phenyl)-3-(2-(trifluoromethyl)pyridin-4-yl)isoindolin-1-amine

InChi Key

FRFZEQFHJDHLJC-WCSIJFPASA-N

InChi Code

InChI=1S/C24H17F4N5/c25-19-6-2-5-18-21(19)22(29)33-23(18,17-7-8-32-20(10-17)24(26,27)28)16-4-1-3-14(9-16)15-11-30-13-31-12-15/h1-13,22,33H,29H2/t22?,23-/m0/s1

SMILES Code

NC1N[C@@](C2=CC=CC(C3=CN=CN=C3)=C2)(C4=CC(C(F)(F)F)=NC=C4)C5=C1C(F)=CC=C5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 451.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yan R. Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs. Transl Neurodegener. 2016 Jul 14;5:13. doi: 10.1186/s40035-016-0061-5. eCollection 2016. Review. PubMed PMID: 27418961; PubMed Central PMCID: PMC4944430.