MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 328501 | Name: Pancuronium Bromide
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pancuronium Bromide, also known as Pavulon and NA-97, is a bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent, Pancuronium bromide is more potent than curare but has less effect on the circulatory system and on histamine release.

Chemical Structure

Pancuronium Bromide
Pancuronium Bromide
CAS#15500-66-0 (bromide)

Theoretical Analysis

MedKoo Cat#: 328501

Name: Pancuronium Bromide

CAS#: 15500-66-0 (bromide)

Chemical Formula: C35H60Br2N2O4

Exact Mass: 0.0000

Molecular Weight: 732.68

Elemental Analysis: C, 57.38; H, 8.25; Br, 21.81; N, 3.82; O, 8.73

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 550.00 2 Weeks
50mg USD 950.00 2 Weeks
100mg USD 1,650.00 2 Weeks
200mg USD 2,450.00 2 Week
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
16974-53-1 (cation) 15500-66-0 (bromide) 22189-36-2 (bromide hydrate)
Synonym
Pancuronium Bromide; NA-97; Org-NA-97; NA97; OrgNA97; NA 97; Org NA 97; Pavulon
IUPAC/Chemical Name
1,1'-((2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3,17-diacetoxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-2,16-diyl)bis(1-methylpiperidin-1-ium) bromide
InChi Key
NPIJXCQZLFKBMV-YTGGZNJNSA-L
InChi Code
InChI=1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1
SMILES Code
C[C@@]12[C@@H](OC(C)=O)[C@@H]([N+]3(C)CCCCC3)C[C@@]1([H])[C@]4([H])CC[C@@]5([H])C[C@H](OC(C)=O)[C@@H]([N+]6(C)CCCCC6)C[C@]5(C)[C@@]4([H])CC2.[Br-].[Br-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Pancuronium dibromide, a bis-quaternary steroid, is a neuromuscular relaxant. Pancuronium dibromide inhibits neuromuscular transmission by competing with acetylcholine for binding sites on nACh receptors.
In vitro activity:
The mechanisms underlying the fade of the tetanic contraction induced by pancuronium were studied in vitro by means of myographical and electrophysiological techniques in the extensor digitorum longus muscle of the rat. Pancuronium (0.5 mumol/l) induced a complete fade of the tetanic contraction while leaving the twitch unaffected. At the same concentration it decreased the amplitude and increased the tetanic rundown of trains of endplate potentials (e.p.ps) evoked in the frequency of 50 Hz. The electrophysiological changes induced by pancuronium were due to decreases in both quantal sizes and quantal contents of the e.p.ps. Reference: Pharmacology. 1994 Oct;49(4):265-70. https://pubmed.ncbi.nlm.nih.gov/7831390/
In vivo activity:
The EFS-induced contraction for the concentration range of gallamine 0.32 microM-0.32 mM was found to differ significantly between the strips treated with pancuronium in the organ bath and their control group. For the guinea-pigs anaesthetized and pretreated with pancuronium a significant difference with control was observed at gallamine concentrations ranging from 0.032-0.32 mM. These results show that pancuronium, added to the organ bath as well as administered intravenously to the guinea-pig, masked the inhibitory muscarinic receptor. Reference: Life Sci. 1995;57(25):2325-33. https://pubmed.ncbi.nlm.nih.gov/7491091/
Solvent mg/mL mM
Solubility
DMSO 100.0 136.48
Ethanol 100.0 136.48
Water 100.0 136.48
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 732.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Gallacci M, Oliveira AC. Pre- and postsynaptic mechanisms involved in tetanic fade induced by pancuronium in the isolated rat muscle. Pharmacology. 1994 Oct;49(4):265-70. doi: 10.1159/000139242. PMID: 7831390. 2. Nagtegaal JE, Siero HL, Dirksen R, Lammers JW, Rodrigues de Miranda JF, Russel FG. Pancuronium masks the prejunctional muscarinic autoreceptor in guinea pig tracheal smooth muscle. Life Sci. 1995;57(25):2325-33. doi: 10.1016/0024-3205(95)02227-a. PMID: 7491091. 3. Pourcyrous M, Leffler CW, Bada HS, Korones SB, Stidham GL, Busija DW. Effects of pancuronium bromide on cerebral blood flow changes during seizures in newborn pigs. Pediatr Res. 1992 Jun;31(6):636-9. doi: 10.1203/00006450-199206000-00019. PMID: 1635828.
In vitro protocol:
1. Gallacci M, Oliveira AC. Pre- and postsynaptic mechanisms involved in tetanic fade induced by pancuronium in the isolated rat muscle. Pharmacology. 1994 Oct;49(4):265-70. doi: 10.1159/000139242. PMID: 7831390.
In vivo protocol:
1. Nagtegaal JE, Siero HL, Dirksen R, Lammers JW, Rodrigues de Miranda JF, Russel FG. Pancuronium masks the prejunctional muscarinic autoreceptor in guinea pig tracheal smooth muscle. Life Sci. 1995;57(25):2325-33. doi: 10.1016/0024-3205(95)02227-a. PMID: 7491091. 2. Pourcyrous M, Leffler CW, Bada HS, Korones SB, Stidham GL, Busija DW. Effects of pancuronium bromide on cerebral blood flow changes during seizures in newborn pigs. Pediatr Res. 1992 Jun;31(6):636-9. doi: 10.1203/00006450-199206000-00019. PMID: 1635828.
1: Radkowski P, Szewczyk M, Czajka A, Samiec M, Braczkowska-Skibińska M. The Influence of Acid-Base Balance on Anesthetic Muscle Relaxants: A Comprehensive Review on Clinical Applications and Mechanisms. Med Sci Monit. 2024 Jul 1;30:e944510. doi: 10.12659/MSM.944510. PMID: 38949163; PMCID: PMC11305051. 2: Nietvelt F, Van Herreweghe I, Godschalx V, Soetens F. Extravascular injection of neuromuscular blocking drugs: A systematic review of current evidence and management. Eur J Anaesthesiol. 2024 May 1;41(5):367-373. doi: 10.1097/EJA.0000000000001967. Epub 2024 Feb 27. PMID: 38410855; PMCID: PMC10990036. 3: Hunter JM, Blobner M. Under-dosing and over-dosing of neuromuscular blocking drugs and reversal agents: beware of the risks. Br J Anaesth. 2024 Mar;132(3):461-465. doi: 10.1016/j.bja.2023.12.001. Epub 2023 Dec 21. PMID: 38135525. 4: Anselmi L, Ducrocq GP, Ruiz-Velasco V, Stocker SD, Higgins SP, Kaufman MP. Functional knockout of the TRPV1 channel has no effect on the exercise pressor reflex in rats. J Physiol. 2023 Dec;601(23):5241-5256. doi: 10.1113/JP285267. Epub 2023 Oct 25. PMID: 37878364. 5: Sakata S, Ono F. Allosteric inhibition of muscle-type nicotinic acetylcholine receptors by a neuromuscular blocking agent pancuronium. PLoS One. 2023 Oct 12;18(10):e0292262. doi: 10.1371/journal.pone.0292262. PMID: 37824562; PMCID: PMC10569638. 6: Das GN, Sharma P, Maani CV. Pancuronium. 2023 Aug 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30855929. 7: Virmani S, Mallik I, Mohire VB, Geelani MA, Minhas HS. Effect of preoperative ivabradine on hemodynamics during elective off-pump CABG. Ann Card Anaesth. 2023 Jul-Sep;26(3):260-267. doi: 10.4103/aca.aca_97_22. PMID: 37470523; PMCID: PMC10451143. 8: Clar DT, Liu M. Nondepolarizing Neuromuscular Blockers. 2023 Jul 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30521249. 9: Kumar NM, Gruhs P, Casini A, Biedermann F, Moreno-Alcántar G, Picchetti P. Electrochemical Detection of Drugs via a Supramolecular Cucurbit[7]uril-Based Indicator Displacement Assay. ACS Sens. 2023 Jul 28;8(7):2525-2532. doi: 10.1021/acssensors.3c00008. Epub 2023 Jun 20. PMID: 37339775; PMCID: PMC10391622. 10: Schilliger L, Najjar C, Paillusseau C, François C, Gandar F, Boughdiri H, Gansuana M. Pancuronium Bromide for Chemical Immobilization of Adult Nile Crocodiles (Crocodylus niloticus): A Field Study. Animals (Basel). 2023 May 9;13(10):1578. doi: 10.3390/ani13101578. PMID: 37238008; PMCID: PMC10215295. 11: Merienne C, Filali S, Marchand C, Lapras B, Paillet C, Pirot F. Predictive stability, novel HPLC-MS analysis and semi-automatic compounding process for the emergency implementation of a production line of pancuronium in injectable solution. Eur J Pharm Sci. 2023 Aug 1;187:106464. doi: 10.1016/j.ejps.2023.106464. Epub 2023 May 10. PMID: 37169099; PMCID: PMC10169324. 12: Lanier WL. Modulation of Cerebral Function by Muscle Afferent Activity, with Reference to Intravenous Succinylcholine. Anesthesiology. 2023 Feb 1;138(2):209-215. doi: 10.1097/ALN.0000000000004437. PMID: 36629464. 13: Liu HK, Lin F, Yu SB, Wu Y, Lu S, Liu YY, Qi QY, Cao J, Zhou W, Li X, Wang H, Zhang DW, Li ZT, Ma D. Highly Water-Soluble Cucurbit[8]uril Derivative as a Broad-Spectrum Neuromuscular Block Reversal Agent. J Med Chem. 2022 Dec 22;65(24):16893-16901. doi: 10.1021/acs.jmedchem.2c01677. Epub 2022 Dec 8. PMID: 36480913. 14: Yamashita M, Egashira Y, Nakamura S, Sakata S, Ono F. Receptor subunit compositions underly distinct potencies of a muscle relaxant in fast and slow muscle fibers. Front Physiol. 2022 Oct 11;13:1026646. doi: 10.3389/fphys.2022.1026646. PMID: 36304584; PMCID: PMC9592714. 15: Dickerson RN, Corley CE, Holmes WL, Byerly S, Filiberto DM, Fischer PE. Gastric feeding intolerance in critically ill patients during sustained pharmacologic neuromuscular blockade. Nutr Clin Pract. 2023 Apr;38(2):350-359. doi: 10.1002/ncp.10911. Epub 2022 Sep 25. PMID: 36156827. 16: Wu Y, Liu YY, Liu HK, Yu SB, Lin F, Zhou W, Wang H, Zhang DW, Li ZT, Ma D. Flexible organic frameworks sequester neuromuscular blocking agents in vitro and reverse neuromuscular block in vivo. Chem Sci. 2022 Jul 20;13(32):9243-9248. doi: 10.1039/d2sc02456j. PMID: 36093029; PMCID: PMC9384803. 17: Ross J, Ramsay DP, Sutton-Smith LJ, Willink RD, Moore JE. Residual neuromuscular blockade in the ICU: a prospective observational study and national survey. Anaesthesia. 2022 Sep;77(9):991-998. doi: 10.1111/anae.15789. Epub 2022 Jul 15. PMID: 35837762. 18: Kim A, Rawls SM. Nicotine-induced C-shape movements in planarians are reduced by antinociceptive drugs: Implications for pain in planarian paroxysm etiology? Brain Res. 2022 Mar 1;1778:147770. doi: 10.1016/j.brainres.2021.147770. Epub 2021 Dec 31. PMID: 34979130; PMCID: PMC8816893. 19: Andrade PV, Souza LS, Santos JM, Alves JFF, Lutke C, Amaral JLG, Vainzof M, Silva HCA. Spinal cord injury-related thermoregulatory impairment masks a fatal malignant hyperthermia crisis: a case report. Can J Anaesth. 2022 Mar;69(3):369-373. English. doi: 10.1007/s12630-021-02170-4. Epub 2021 Dec 13. PMID: 34904211. 20: Camargo WL, Kushmerick C, Pinto E, Souza N, Cavalcante W, Souza-Neto FP, Guatimosim S, Prado M, Guatimosim C, Naves LA. Homeostatic plasticity induced by increased acetylcholine release at the mouse neuromuscular junction. Neurobiol Aging. 2022 Feb;110:13-26. doi: 10.1016/j.neurobiolaging.2021.10.010. Epub 2021 Oct 29. PMID: 34844076.