DMI-9523, also known as DA-DKP; Ampion; DM-9523; DADKP, is nuclear factor NF-κB activation inhibitor potentially for the treatment of osteoarthritis. Aspartyl-alanyl- diketopiperazine (DA-DKP) is generated by cleavage and cyclization from the N-terminus of human albumin during the preparation of commercial serum albumin product. Antigen-stimulated human T lymphocytes produce significantly lower quantities of interferon-gamma and tumor necrosis factor-alpha after stimulation in vitro in the presence of DA-DKP. DA-DKP can modulate the inflammatory immune response through a molecular pathway implicated in T- lymphocyte anergy.
MedKoo Cat#: 326908
Name: DMI-9523
CAS#: 110954-19-3
Chemical Formula: C7H10N2O4
Exact Mass: 186.0641
Molecular Weight: 186.17
Elemental Analysis: C, 45.16; H, 5.41; N, 15.05; O, 34.38
The following data is based on the product molecular weight 186.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
