GNE-9815 is a Type II pan-RAF inhibitor. In vivo evaluation of GNE-9815 in combination with the MEK inhibitor cobimetinib demonstrated synergistic MAPK pathway modulation in an HCT116 xenograft mouse model. To the best of our knowledge, GNE-9815 is among the most highly kinase-selective RAF inhibitors reported to date.
MedKoo Cat#: 464594
Name: GNE-9815
CAS#: 2729996-45-4
Chemical Formula: C26H22FN5O2
Exact Mass: 455.1758
Molecular Weight: 455.49
Elemental Analysis: C, 68.56; H, 4.87; F, 4.17; N, 15.38; O, 7.02
The following data is based on the product molecular weight 455.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
