Zotepine | CAS#26615-21-4 | Antipsychotic agent

MedKoo Cat#: 328201 | Name: Zotepine

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Zotepine is a dibenzothiazepine-class atypical antipsychotic that acts as a dopamine D₂ and serotonin 5-HT₂A receptor antagonist, with additional affinity for D₁, D₄, and α₁-adrenergic receptors. It exhibits high lipophilicity and crosses the blood-brain barrier efficiently, contributing to its central nervous system effects. Zotepine also inhibits presynaptic dopamine reuptake, distinguishing it from other atypical antipsychotics and potentially enhancing its efficacy in schizophrenia treatment.

Chemical Structure

Zotepine

CAS#26615-21-4

Theoretical Analysis

MedKoo Cat#: 328201

Name: Zotepine

CAS#: 26615-21-4

Chemical Formula: C18H18ClNOS

Exact Mass: 331.0798

Molecular Weight: 331.86

Elemental Analysis: C, 65.15; H, 5.47; Cl, 10.68; N, 4.22; O, 4.82; S, 9.66

Price and Availability

Size	Price	Availability
10mg	USD 375.00	2 weeks
25mg	USD 650.00	2 weeks
50mg	USD 1,000.00	2 weeks

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Related CAS #

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Synonym

Zotepine

IUPAC/Chemical Name

2-((8-chlorodibenzo[b,f]thiepin-10-yl)oxy)-N,N-dimethylethan-1-amine

InChi Key

HDOZVRUNCMBHFH-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3

SMILES Code

ClC1=CC=C(SC2=CC=CC=C2C=C3OCCN(C)C)C3=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 331.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Chan HY, Lin AS, Chen KP, Cheng JS, Chen YY, Tsai CJ. An open-label, randomized, controlled trial of zotepine and risperidone for acutely ill, hospitalized, schizophrenic patients with symptoms of agitation. J Clin Psychopharmacol. 2013 Dec;33(6):747-52. doi: 10.1097/JCP.0b013e31829e8168. PubMed PMID: 24100785. 2: Lin CC, Chiu HJ, Chen JY, Liou YJ, Wang YC, Chen TT, Bai YM. Switching from clozapine to zotepine in patients with schizophrenia: a 12-week prospective, randomized, rater blind, and parallel study. J Clin Psychopharmacol. 2013 Apr;33(2):211-4. doi: 10.1097/JCP.0b013e31828700c7. PubMed PMID: 23422395. 3: Khairkar P, Gupta N, Varma SK. Zotepine-induced convulsive seizures in a chronic case of treatment resistant paranoid schizophrenia. Indian J Pharmacol. 2013 Jan-Feb;45(1):95-7. doi: 10.4103/0253-7613.106447. PubMed PMID: 23543675; PubMed Central PMCID: PMC3608308. 4: Chen IM, Hsieh MH, Hwang TJ, Liu CC. Zotepine-related myopathy in a patient with schizophrenia. Eur J Clin Pharmacol. 2013 Mar;69(3):725-6. doi: 10.1007/s00228-012-1346-y. Epub 2012 Jul 14. PubMed PMID: 22797903. 5: Pai MS, Yang SN, Shiah IS. Rifampin-zotepine interaction reduces effectiveness of antipsychotic drugs in a stable schizophrenia patient. Psychiatry Clin Neurosci. 2012 Oct;66(6):538. doi: 10.1111/j.1440-1819.2012.02370.x. PubMed PMID: 23066778. 6: Subramanian S, Rummel-Kluge C, Hunger H, Schmid F, Schwarz S, Kissling W, Leucht S, Komossa K. Zotepine versus other atypical antipsychotics for schizophrenia. Cochrane Database Syst Rev. 2010 Oct 6;(10):CD006628. doi: 10.1002/14651858.CD006628.pub3. Review. PubMed PMID: 20927748; PubMed Central PMCID: PMC4161491. 7: Huang WL, Chang LR. Hyperhidrosis under combination of zotepine and haloperidol alleviated by aripiprazole. Psychiatry Clin Neurosci. 2012 Apr;66(3):245. doi: 10.1111/j.1440-1819.2012.02328.x. PubMed PMID: 22443252. 8: Suzuki Y, Watanabe J, Sugai T, Fukui N, Ono S, Tsuneyama N, Saito M, Someya T. Improvement in QTc prolongation induced by zotepine following a switch to perospirone. Psychiatry Clin Neurosci. 2012 Apr;66(3):244. doi: 10.1111/j.1440-1819.2012.02321.x. PubMed PMID: 22443250. 9: Hsu WY, Kuo SY, Huang SS, Chang TG, Chiu NY. Valproate and high dosage of zotepine induced acute delirium: a case report. Br J Clin Pharmacol. 2012 Mar;73(3):486-8. doi: 10.1111/j.1365-2125.2011.04119.x. PubMed PMID: 21988532; PubMed Central PMCID: PMC3370356. 10: Hsu WC, Lin ST, Chen CC, Tsang HY, Huang MF. A self-limiting case of atypical neuroleptic malignant syndrome associated with zotepine. J Clin Psychopharmacol. 2011 Oct;31(5):667-9. doi: 10.1097/JCP.0b013e31822c2a04. PubMed PMID: 21881455.