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MedKoo Cat#: 206729 | Name: CT-2584

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CT-2584 is an angiogenesis inhibitor and lysophosphatidic acid acyltransferase inhibitor potentially for the treatment of cancer. CT-2584 inhibits phospholipid signaling. By inhibiting CTP:choline-phosphate cytidylyltransferase (CT), CT-2584 caused de novo phospholipid biosynthesis via PA to be shunted away from phosphatidylcholine (PC) and into phosphatidylinositol (PI), the latter of which was doubled in a variety of CT-2584-treated tumor cell lines. CT-2584 effects a novel mechanism of cytotoxicity to cancer cells, involving a specific modulation of phospholipid metabolism.

Chemical Structure

CT-2584
CT-2584
CAS#166981-13-1 (free base)

Theoretical Analysis

MedKoo Cat#: 206729

Name: CT-2584

CAS#: 166981-13-1 (free base)

Chemical Formula: C30H55N5O3

Exact Mass: 533.4305

Molecular Weight: 533.80

Elemental Analysis: C, 67.50; H, 10.39; N, 13.12; O, 8.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
353525-62-9 (mesylate) 166981-13-1 (free base)
Synonym
CT-2584; CT2584; CT 2584.
IUPAC/Chemical Name
1-(11-(dodecylamino)-10-hydroxyundecyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione
InChi Key
MZNMZWZGUGFQJP-UHFFFAOYSA-N
InChi Code
InChI=1S/C30H55N5O3/c1-4-5-6-7-8-9-10-13-16-19-22-31-24-26(36)21-18-15-12-11-14-17-20-23-35-29(37)27-28(32-25-33(27)2)34(3)30(35)38/h25-26,31,36H,4-24H2,1-3H3
SMILES Code
O=C(N1CCCCCCCCCC(O)CNCCCCCCCCCCCC)N(C)C2=C(N(C)C=N2)C1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 533.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bonfil RD. CT-2584 (Cell Therapeutics). Curr Opin Investig Drugs. 2001 Mar;2(3):424-7. PubMed PMID: 11575717. 2: Cheeseman SL, Brannan M, McGown A, Khan P, Gardner C, Gumbrell L, Dickens D, Ranson M. Phase I and pharmacologic study of CT-2584 HMS, a modulator of phosphatidic acid, in adult patients with solid tumours. Br J Cancer. 2000 Dec;83(12):1599-606. PubMed PMID: 11104552; PubMed Central PMCID: PMC2363467. 3: Finney RE, Nudelman E, White T, Bursten S, Klein P, Leer LL, Wang N, Waggoner D, Singer JW, Lewis RA. Pharmacological inhibition of phosphatidylcholine biosynthesis is associated with induction of phosphatidylinositol accumulation and cytolysis of neoplastic cell lines. Cancer Res. 2000 Sep 15;60(18):5204-13. PubMed PMID: 11016649. 4: Khan P, Abbas S, Cheeseman S, Ranson M, McGown AT. Development and validation of a sensitive solid-phase extraction and high-performance liquid chromatography assay for the novel antitumour agent CT2584 in human plasma. J Chromatogr B Biomed Sci Appl. 1999 Jan 22;721(2):279-84. PubMed PMID: 10052700. 5: Phase I clinical data on novel anticancer, antiangiogenesis drug. Oncology (Williston Park). 1998 Sep;12(9):1395. PubMed PMID: 9778687. 6: Marucci L, Varticovski L, Arias IM. Effect of a xanthine analog on human hepatocellular carcinoma cells (Alexander) in culture and in xenografts in SCID mice. Hepatology. 1997 Nov;26(5):1195-202. PubMed PMID: 9362362. 7: Shau H, Kim AT, Hedrick CC, Lusis AJ, Tompkins C, Finney R, Leung DW, Paglia DE. Endogenous natural killer enhancing factor-B increases cellular resistance to oxidative stresses. Free Radic Biol Med. 1997;22(3):497-507. PubMed PMID: 8981042. 8: MOUNT RA, FLOYD TM. A dysentery outbreak aboard a cruiser in Apra Harbor, Guam, Marianas Islands. U S Nav Med Bull. 1948 Mar-Apr;48(2):240-9. PubMed PMID: 18906975.