Synonym
A-77000; A 77000; A77000; DN-2327; DN 2327; DN2327; Pazinaclone
IUPAC/Chemical Name
2-(7-chloro-1,8-naphthyridin-2-yl)-3-(2-oxo-2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)ethyl)isoindolin-1-one
InChi Key
DPGKFACWOCLTCA-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H23ClN4O4/c26-20-7-5-16-6-8-21(28-23(16)27-20)30-19(17-3-1-2-4-18(17)24(30)32)15-22(31)29-11-9-25(10-12-29)33-13-14-34-25/h1-8,19H,9-15H2
SMILES Code
O=C(N(CC1)CCC21OCCO2)CC3N(C4=NC5=NC(Cl)=CC=C5C=C4)C(C6=C3C=CC=C6)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
478.93
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Pazinaclone. A 77000, DN 2327. Drugs R D. 1999 Jul;2(1):57-9. PubMed PMID: 10610295.
2: Kondo T, Yoshida K, Tanayama S. Absorption of the anxiolytic pazinaclone in animals as a criterion for species selection for toxicity studies. Arzneimittelforschung. 1996 Sep;46(9):839-43. PubMed PMID: 8876929.
3: Kondo T, Yoshida K, Yamamoto M, Tanayama S. Enantiomeric toxicokinetics of the new isoindoline anxiolytic pazinaclone in rats and dogs. Arzneimittelforschung. 1996 Jan;46(1):11-14. PubMed PMID: 8821511.
4: Kondo T, Yoshida K, Yoshimura Y, Tanayama S. Enantioselective pharmacokinetics in animals of pazinaclone, a new isoindoline anxiolytic, and its active metabolite. Biopharm Drug Dispos. 1995 Dec;16(9):755-73. PubMed PMID: 8580400.
5: Kondo T, Hamasaki K, Yamaguchi M, Aoki I, Yoshida K, Yoshimura Y, Tanayama S. Enantioselective determination of pazinaclone, a new isoindoline anxiolytic, and its active metabolite in rat plasma by high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1995 Apr 21;666(2):291-7. PubMed PMID: 7633605.
6: Evans SM, Foltin RW, Levin FR, Fischman MW. Behavioral and subjective effects of DN-2327 (pazinaclone) and alprazolam in normal volunteers. Behav Pharmacol. 1995 Mar;6(2):176-186. PubMed PMID: 11224325.
7: Hussein Z, Mulford DJ, Bopp BA, Granneman GR. Stereoselective pharmacokinetics of pazinaclone, a new non-benzodiazepine anxiolytic, and its active metabolite in healthy subjects. Br J Clin Pharmacol. 1993 Oct;36(4):357-61. PubMed PMID: 12959315; PubMed Central PMCID: PMC1364690.
8: Hussein Z, Mulford DJ, Bopp BA, Granneman GR. Differences in the stereoselective pharmacokinetics of pazinaclone (DN-2327), a new anxiolytic, and its active metabolite after intravenous and oral single doses to dogs. Drug Metab Dispos. 1993 Sep-Oct;21(5):805-10. PubMed PMID: 7902240.
