MedKoo Cat#: 328109 | Name: Leminoprazole

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Leminoprazole, an acid pump inhibitor, has a mucosal protective effect against various experimental gastric lesion.

Chemical Structure

Leminoprazole
Leminoprazole
CAS#104340-86-5

Theoretical Analysis

MedKoo Cat#: 328109

Name: Leminoprazole

CAS#: 104340-86-5

Chemical Formula: C19H23N3OS

Exact Mass: 341.1562

Molecular Weight: 341.47

Elemental Analysis: C, 66.83; H, 6.79; N, 12.31; O, 4.69; S, 9.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
104340-86-5 177541-00-3 (isomer (-)-) 177541-01-4 (isomer (+)-)
Synonym
Leminoprazole
IUPAC/Chemical Name
2-(((1H-benzo[d]imidazol-2-yl)sulfinyl)methyl)-N-isobutyl-N-methylaniline
InChi Key
PSIREIZGKQBEEO-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H23N3OS/c1-14(2)12-22(3)18-11-7-4-8-15(18)13-24(23)19-20-16-9-5-6-10-17(16)21-19/h4-11,14H,12-13H2,1-3H3,(H,20,21)
SMILES Code
O=S(C1=NC2=CC=CC=C2N1)CC3=CC=CC=C3N(CC(C)C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 341.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Takahashi S, Okabe S. Mechanism by which orally administered leminoprazole stimulates mucus synthesis in rats. Pharmacology. 1998 Jul;57(1):47-56. PubMed PMID: 9670212. 2: Takahashi S, Okabe S. The cytoprotective effect of leminoprazole on indomethacin-induced damage to rabbit gastric mucosal cells. J Pharmacol Exp Ther. 1996 Nov;279(2):975-82. PubMed PMID: 8930207. 3: Okabe S, Amagase K, Fujita H, Iwata K, Satake N, Shibata S. Vasoinhibitory effect of leminoprazole, a H+,K(+)-ATPase inhibitor, on rat aortic rings. Gen Pharmacol. 1996 Jan;27(1):117-21. PubMed PMID: 8742507. 4: Okabe S, Shimosako K, Harada H. Antisecretory effect of leminoprazole on histamine-stimulated gastric acid secretion in dogs: potent local effect. Jpn J Pharmacol. 1995 Oct;69(2):91-100. PubMed PMID: 8569059. 5: Takahashi S, Tsukahara T, Okabe S. Effects of acid-degraded products of leminoprazole on acid secretion, mucus secretion and synthesis, and indomethacin-induced damage in cell culture. J Physiol Pharmacol. 1998 Mar;49(1):99-110. PubMed PMID: 9594414. 6: Matsukura H, Masuda M, Uchida A, Kamishiro T. [Effect of a new antiulcer drug, leminoprazole, on the gastric mucosal H+,K(+)-ATPase activity in rats]. Nihon Yakurigaku Zasshi. 1994 Aug;104(2):91-100. Japanese. PubMed PMID: 7927073. 7: Tsukimi Y, Nozue C, Okabe S. Effects of leminoprazole, omeprazole and sucralfate on indomethacin-induced delayed healing of kissing gastric ulcers in rats. J Gastroenterol Hepatol. 1996 Apr;11(4):335-40. PubMed PMID: 8713699. 8: Takahashi S, Yamazaki T, Okabe S. Leminoprazole protects cultured gastric mucosal cells against damage caused by ethanol, indometacin and taurocholate. Pharmacology. 1997 Mar;54(3):118-26. PubMed PMID: 9127434. 9: Takahashi S, Nakamura E, Okabe S. Stimulatory effect of leminoprazole on secretion and synthesis of mucus by rabbit gastric mucosal cells. J Pharmacol Exp Ther. 1995 Dec;275(3):1396-401. PubMed PMID: 8531108. 10: Saito E, Matsuo Y. Inhibitory effect of leminoprazole on acid secretion in parietal cells isolated from guinea pig gastric mucosa. Jpn J Pharmacol. 1995 May;68(1):19-23. PubMed PMID: 7494378.