Epertinib, also known as S-22611, is an oral reversible dual tyrosine kinase inhibitor of EGFR and HER2, currently under trials in patients with solid tumours. S-222611 selectively inhibited kinases with IC50 s below 10 nmol/L. S-222611 also inhibited intracellular kinase activity and the growth of EGFR-expressing and HER2-expressing cancer cells. In addition, S-222611 showed potent antitumor activity over lapatinib in a variety of xenograft models.
MedKoo Cat#: 327008
Name: Epertinib
CAS#: 908305-13-5 (free base)
Chemical Formula: C30H27ClFN5O3
Exact Mass: 559.1786
Molecular Weight: 560.03
Elemental Analysis: C, 64.34; H, 4.86; Cl, 6.33; F, 3.39; N, 12.51; O, 8.57
The following data is based on the product molecular weight 560.03 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
