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MedKoo Cat#: 525919 | Name: PF 10040

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF 10040 is a platelet activating factor (PAF) antagonist.

Chemical Structure

PF 10040
CAS#132928-46-2

Theoretical Analysis

MedKoo Cat#: 525919

Name: PF 10040

CAS#: 132928-46-2

Chemical Formula: C20H24ClNO2

Exact Mass:

Molecular Weight: 345.87

Elemental Analysis: C, 69.45; H, 6.99; Cl, 10.25; N, 4.05; O, 9.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PF 10040; PF10040; PF-10040.
IUPAC/Chemical Name
Isoquinoline, 1-(2-(3,4-dimethoxyphenyl)ethyl)-3,4-dihydro-6-methyl-, hydrochloride
InChi Key
FJHOALINTTUIKP-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H23NO2.ClH/c1-14-4-7-17-16(12-14)10-11-21-18(17)8-5-15-6-9-19(22-2)20(13-15)23-3;/h4,6-7,9,12-13H,5,8,10-11H2,1-3H3;1H
SMILES Code
CC1=CC2=C(C(CCC3=CC=C(OC)C(OC)=C3)=NCC2)C=C1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 345.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Herd CM, Donigi-Gale D, Shoupe TS, Kilfeather SA, Okiji SA, Page CP. Effect of PF 10040 on PAF-induced airway responses in neonatally immunized rabbits. Br J Pharmacol. 1994 Jan;111(1):7-12. PubMed PMID: 8012726; PubMed Central PMCID: PMC1910040. 2: Wallace JL, McKnight GW, Donigi-Gale D, Shoupe TS, Granger DN. Protective effects of PF-10040 in experimental NSAID-gastritis: role of leukocytes, leukotrienes and PAF. J Lipid Mediat. 1993 Jun;7(2):183-96. PubMed PMID: 8400119. 3: Rossi AG, Norman KE, Donigi-Gale D, Shoupe TS, Edwards R, Williams TJ. The role of complement, platelet-activating factor and leukotriene B4 in a reversed passive Arthus reaction. Br J Pharmacol. 1992 Sep;107(1):44-9. PubMed PMID: 1330163; PubMed Central PMCID: PMC1907593.