MedKoo Cat#: 562329 | Name: BHPI

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BHPI is a potent noncompetitive ERα biomodulator. It acts by selectively blocking proliferation of drug-resistant ERα-positive breast and ovarian cancer cells.

Chemical Structure

BHPI
BHPI
CAS#56632-39-4

Theoretical Analysis

MedKoo Cat#: 562329

Name: BHPI

CAS#: 56632-39-4

Chemical Formula: C21H17NO3

Exact Mass: 331.1208

Molecular Weight: 331.37

Elemental Analysis: C, 76.12; H, 5.17; N, 4.23; O, 14.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BHPI;
IUPAC/Chemical Name
3,3-Bis-(4-hydroxy-phenyl)-7-methyl-1,3-dihydro-indol-2-one
InChi Key
FABLAHMQSQFDHR-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H17NO3/c1-13-3-2-4-18-19(13)22-20(25)21(18,14-5-9-16(23)10-6-14)15-7-11-17(24)12-8-15/h2-12,23-24H,1H3,(H,22,25)
SMILES Code
O=C1NC2=C(C=CC=C2C)C1(C3=CC=C(O)C=C3)C4=CC=C(O)C=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 331.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mamin FA, Islam MS, Rumana FS, Faruqui F. Profile of stroke patients treated at a rehabilitation centre in Bangladesh. BMC Res Notes. 2017 Oct 27;10(1):520. doi: 10.1186/s13104-017-2844-x. PubMed PMID: 29078803; PubMed Central PMCID: PMC5658960. 2: Somasundaram S, Kamaraj E, Hwang SJ, Park S. Structural, photophysical, and theoretical studies of imidazole-based excited-state intramolecular proton transfer molecules. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Feb 15;191:325-335. doi: 10.1016/j.saa.2017.10.023. Epub 2017 Oct 14. PubMed PMID: 29055277. 3: Mao C, Livezey M, Kim JE, Shapiro DJ. Antiestrogen Resistant Cell Lines Expressing Estrogen Receptor α Mutations Upregulate the Unfolded Protein Response and are Killed by BHPI. Sci Rep. 2016 Oct 7;6:34753. doi: 10.1038/srep34753. PubMed PMID: 27713477; PubMed Central PMCID: PMC5054422. 4: Shapiro DJ, Livezey M, Yu L, Zheng X, Andruska N. Anticipatory UPR Activation: A Protective Pathway and Target in Cancer. Trends Endocrinol Metab. 2016 Oct;27(10):731-741. doi: 10.1016/j.tem.2016.06.002. Epub 2016 Jun 25. Review. PubMed PMID: 27354311; PubMed Central PMCID: PMC5035594. 5: Andruska ND, Zheng X, Yang X, Mao C, Cherian MM, Mahapatra L, Helferich WG, Shapiro DJ. Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4737-42. doi: 10.1073/pnas.1403685112. Epub 2015 Mar 30. PubMed PMID: 25825714; PubMed Central PMCID: PMC4403155. 6: Habib MM. Ergonomic risk factor identification for sewing machine operators through supervised occupational therapy fieldwork in Bangladesh: A case study. Work. 2015;50(3):357-62. doi: 10.3233/WOR-151991. PubMed PMID: 25659369. 7: Lindstrom-Hazel D, Habib MM, Nahar N, Ullah MM. Work in Bangladesh. Work. 2015;50(3):343-5. doi: 10.3233/WOR-151989. PubMed PMID: 25659368. 8: Moniruzzaman, Saha PC, Habib MM. Community based rehabilitation: Does it really improve the level of productivity among persons with physical disabilities? Work. 2015;50(3):395-401. doi: 10.3233/WOR-131795. PubMed PMID: 24284688. 9: Müller-Esch G, von der Lühe C, Ball P, Henkel E, Schlüter KJ, Wood WG, Scriba PC. Comparative study of hormonal counterregulation during GCIIS-guided hypoglycemia tests using human proinsulin and human insulin (recombinant DNA). Horm Metab Res Suppl. 1988;18:24-33. PubMed PMID: 2847967. 10: Rice RW, Kroning J, Critchlow V. Effects of stress on plasma corticosterone and growth hormone levels in rats with median eminence-pituitary islands. Neuroendocrinology. 1975;19(4):339-51. PubMed PMID: 1226227.