NVS-SM2 is a potent, orally active, small-molecule enhancer of SMN2 splicing. NVS-SM2 binds to and stabilizing the U1 snRNP:5′ss RNA complex. NVS-SM2 shows increased exon 7 inclusion and upregulated SMN protein expression in both SMA patient fibroblasts and SMNΔ7 5025-mouse myoblasts.
MedKoo Cat#: 526828
Name: NVS-SM2
CAS#: 1562333-92-9
Chemical Formula: C23H30N6O
Exact Mass: 406.2481
Molecular Weight: 406.53
Elemental Analysis: C, 67.95; H, 7.44; N, 20.67; O, 3.94
The following data is based on the product molecular weight 406.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
