Terbinafine lactate | CAS#78628-80-5 | 91161-71-6

MedKoo Cat#: 326816 | Name: Terbinafine lactate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Terbinafine is a synthetic allylamine antifungal, is used topically for skin infections. Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in methanol and dichloromethane, soluble in ethanol, and slightly soluble in water. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the fungal cell membrane synthesis pathway. Because terbinafine prevents conversion of squalene to lanosterol, ergosterol cannot be synthesized. This is thought to change cell membrane permeability, causing fungal cell lysis. (last updated: 8/11/2016).

Chemical Structure

Terbinafine lactate

CAS#335276-86-3 (lactate)

Theoretical Analysis

MedKoo Cat#: 326816

Name: Terbinafine lactate

CAS#: 335276-86-3 (lactate)

Chemical Formula: C24H31NO3

Exact Mass:

Molecular Weight: 381.52

Elemental Analysis: C, 75.56; H, 8.19; N, 3.67; O, 12.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

91161-71-6 (free base) 78628-80-5 (HCl) 335276-86-3 (lactate)

Synonym

DRG-0286; SF 86-327 hydrochloride; Terbinafine hydrochloride; Lamisil; Lamisil AT; Lamisil Krem.

IUPAC/Chemical Name

(2E)-N,6,6-Trimethyl-N-(1-naphthylmethyl)hept-2-en-4-yn-1-amine lactate

InChi Key

QDQJADKSEQHPFI-SZKNIZGXSA-N

InChi Code

InChI=1S/C21H25N.C3H6O3/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19;1-2(4)3(5)6/h5-7,9-14H,16-17H2,1-4H3;2,4H,1H3,(H,5,6)/b9-5+;

SMILES Code

CC(C)(C)C#C/C=C/CN(C)CC1=C2C=CC=CC2=CC=C1.OC(C)C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Related CAS# CAS#91161-71-6 (Terbinafine free base). CAS#78628-80-5 (Terbinafine hydrochloride)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 381.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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