Synonym
LY 203647; LY203647; LY-203647.
IUPAC/Chemical Name
Ethanone, 1-(2-hydroxy-3-propyl-4-(4-(2-(4-(1H-tetrazol-5-yl)butyl)-2H-tetrazol-5-yl)butoxy)phenyl)-
SMILES Code
C(C)(c1c(c(c(cc1)OCCCCc1nnn(n1)CCCCc1nnn[nH]1)CCC)O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Preparing Stock Solutions
The following data is based on the
product
molecular weight
442.52
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Mancuso G, Cusumano V, Cook JA, Smith E, Squadrito F, Blandino G, Teti G. Efficacy of tumor necrosis factor alpha and eicosanoid inhibitors in experimental models of neonatal sepsis. FEMS Immunol Med Microbiol. 1994 Jun;9(1):49-54. PubMed PMID: 7920463.
2: Passmore JC, Jimenez AE. Effectiveness of dual cyclooxygense and leukotriene blockade with ibuprofen and LY203647 during canine endotoxic shock. Circ Shock. 1993 Jan;39(1):21-8. PubMed PMID: 8481974.
3: Hahn RA, MacDonald BR, Morgan E, Potts BD, Parli CJ, Rinkema LE, Whitesitt CA, Marshall WS. Evaluation of LY203647 on cardiovascular leukotriene D4 receptors and myocardial reperfusion injury. J Pharmacol Exp Ther. 1992 Mar;260(3):979-89. PubMed PMID: 1312172.
4: Li EJ, Cook JA, Ashton S, Wise WC, Halushka PV. Effect of the LTD4 receptor antagonist LY203647 on endotoxic shock sequelae in the rat. Eur J Pharmacol. 1991 Jun 25;199(2):221-5. PubMed PMID: 1954979.
5: Fink MP, Kruithoff KL, Antonsson JB, Wang HL, Rothschild HR. Delayed treatment with an LTD4/E4 antagonist limits pulmonary edema in endotoxic pigs. Am J Physiol. 1991 May;260(5 Pt 2):R1007-13. PubMed PMID: 1852125.
6: Cohn SM, Kruithoff KL, Rothschild HR, Wang HL, Antonsson JB, Heard SO, Fink MP. Leukotriene C4 induces mesenteric hypoperfusion and intestinal intramural acidosis in pigs. J Surg Res. 1991 Apr;50(4):303-7. PubMed PMID: 2020183.
7: Cohn SM, Kruithoff KL, Rothschild HR, Wang HL, Antonsson JB, Fink MP. Beneficial effects of LY203647, a novel leukotriene C4/D4 antagonist, on pulmonary function and mesenteric perfusion in a porcine model of endotoxic shock and ARDS. Circ Shock. 1991 Jan;33(1):7-16. PubMed PMID: 2009603.
8: Marshall WS, Sigmund SK, Whitesitt CA, Lifer SL, Roman CR, Rinkema LE, Hahn RA, Fleisch JH. Leukotriene (LT) receptor antagonists. Heterocycle-linked tetrazoles and carboxylic acids. LY203647. Agents Actions. 1989 Jun;27(3-4):309-12. PubMed PMID: 2552762.
