LY 191704 | CAS#146117-78-4 | 5α-reductase inhibitor

MedKoo Cat#: 525505 | Name: LY 191704

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY 191704 is a 5α-reductase type 1 inhibitor that has potential for the treatment of disorders associated with the overproduction of dihydrotestosterone such as androgenetic alopecia and prostatic hyperplasia. LY 191704 also has potential in the treatment of acne.

Chemical Structure

LY 191704

CAS#146117-78-4

Theoretical Analysis

MedKoo Cat#: 525505

Name: LY 191704

CAS#: 146117-78-4

Chemical Formula: C14H16ClNO

Exact Mass: 249.0920

Molecular Weight: 249.74

Elemental Analysis: C, 67.33; H, 6.46; Cl, 14.20; N, 5.61; O, 6.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

LY 191704; LY191704; LY-191704.

IUPAC/Chemical Name

Benzo(f)quinolin-3(2H)-one, 8-chloro-1,4,4a,5,6,10b-hexahydro-4-methyl-, trans-

InChi Key

WQBIOEFDDDEARX-STQMWFEESA-N

InChi Code

InChI=1S/C14H16ClNO/c1-16-13-6-2-9-8-10(15)3-4-11(9)12(13)5-7-14(16)17/h3-4,8,12-13H,2,5-7H2,1H3/t12-,13-/m0/s1

SMILES Code

O=C1N(C)[C@@]2([H])CCC3=CC(Cl)=CC=C3[C@]2([H])CC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 249.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Makrantonaki E, Zouboulis CC. Testosterone metabolism to 5alpha-dihydrotestosterone and synthesis of sebaceous lipids is regulated by the peroxisome proliferator-activated receptor ligand linoleic acid in human sebocytes. Br J Dermatol. 2007 Mar;156(3):428-32. PubMed PMID: 17300229. 2: Issa S, Schnabel D, Feix M, Wolf L, Schaefer HE, Russell DW, Schweikert HU. Human osteoblast-like cells express predominantly steroid 5alpha-reductase type 1. J Clin Endocrinol Metab. 2002 Dec;87(12):5401-7. PubMed PMID: 12466325. 3: Guarna A, Occhiato EG, Scarpi D, Zorn C, Danza G, Comerci A, Mancina R, Serio M. Synthesis of 8-chloro-benzo[c]quinolizin-3-ones as potent and selective inhibitors of human steroid 5alpha-reductase 1. Bioorg Med Chem Lett. 2000 Feb 21;10(4):353-6. PubMed PMID: 10714498. 4: Farid NA, Coleman NL. High-performance liquid chromatographic determination of the enantiomers of the benzoquinolinone LY191704, a human type 1 5 alpha-reductase inhibitor, in plasma. J Chromatogr B Biomed Sci Appl. 1997 Mar 28;691(1):212-6. PubMed PMID: 9140778. 5: Farid NA, Schreiner KM, Coleman NL, Van Lier RB, Wrighton SA. Stereoselective disposition of the enantiomers of the benzoquinolinone LY191704, a human type I 5 alpha-reductase inhibitor. Differences between rats and dogs. Drug Metab Dispos. 1996 Oct;24(10):1162-5. PubMed PMID: 8894520. 6: Neubauer BL, Gray HM, Hanke CW, Hirsch KS, Hsiao KC, Jones CD, Kumar MV, Lawhorn DE, Lindzey J, McQuaid L, Tindall DJ, Toomey RE, Yao RC, Audia JE. LY191704 inhibits type I steroid 5 alpha-reductase in human scalp. J Clin Endocrinol Metab. 1996 Jun;81(6):2055-60. PubMed PMID: 8964828. 7: Hirsch KS, Jones CD, Audia JE, Andersson S, McQuaid L, Stamm NB, Neubauer BL, Pennington P, Toomey RE, Russell DW. LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5277-81. PubMed PMID: 8389478; PubMed Central PMCID: PMC46699.