JNJ-26990990 | CAS#877316-38-6 | anticonvulsant

MedKoo Cat#: 525317 | Name: JNJ-26990990

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JNJ-26990990 is a broad-spectrum anticonvulsant drug as a second-generation followup to the marketed drug topiramate. It was designed to have the same anticonvulsant effects as topiramate, but without the side effects associated with topiramate's carbonic anhydrase inhibition. It also has potential use in the treatment of inflammatory pain, neuropathic pain, and depression. JNJ-26990990 entered phase II clinical trials in October 2007.

Chemical Structure

JNJ-26990990

CAS#877316-38-6

Theoretical Analysis

MedKoo Cat#: 525317

Name: JNJ-26990990

CAS#: 877316-38-6

Chemical Formula: C9H10N2O2S2

Exact Mass: 242.0184

Molecular Weight: 242.32

Elemental Analysis: C, 44.61; H, 4.16; N, 11.56; O, 13.21; S, 26.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

JNJ-26990990; JNJ26990990; JNJ 26990990.

IUPAC/Chemical Name

Sulfamide, (benzo(b)thien-3-ylmethyl)-

InChi Key

AWSKBQNOSRREEY-UHFFFAOYSA-N

InChi Code

InChI=1S/C9H10N2O2S2/c10-15(12,13)11-5-7-6-14-9-4-2-1-3-8(7)9/h1-4,6,11H,5H2,(H2,10,12,13)

SMILES Code

O=S(NCC1=CSC2=CC=CC=C21)(N)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 242.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Di Fiore A, De Simone G, Alterio V, Riccio V, Winum JY, Carta F, Supuran CT. The anticonvulsant sulfamide JNJ-26990990 and its S,S-dioxide analog strongly inhibit carbonic anhydrases: solution and X-ray crystallographic studies. Org Biomol Chem. 2016 Jun 7;14(21):4853-8. doi: 10.1039/c6ob00803h. Epub 2016 May 6. PubMed PMID: 27151329. 2: Lin R, Weaner LE, Hoerr DC, Salter R, Gong Y. Expeditious syntheses of stable and radioactive isotope-labeled anticonvulsant agent, JNJ-26990990, and its metabolites. J Labelled Comp Radiopharm. 2013 Jan;56(1):22-6. doi: 10.1002/jlcr.3013. Epub 2013 Jan 10. PubMed PMID: 24285137. 3: Parker MH, Smith-Swintosky VL, McComsey DF, Huang Y, Brenneman D, Klein B, Malatynska E, White HS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Iannucci R, Leclercq L, Cuyckens F, Reitz AB, Maryanoff BE. Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies. J Med Chem. 2009 Dec 10;52(23):7528-36. doi: 10.1021/jm801432r. PubMed PMID: 19388676.