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MedKoo Cat#: 525262 | Name: Icaridin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Icaridin, also known as picaridin and KBR 3023, is an insect repellent. It has broad efficacy against various insects and is almost colorless and odorless.

Chemical Structure

Icaridin
Icaridin
CAS#119515-38-7

Theoretical Analysis

MedKoo Cat#: 525262

Name: Icaridin

CAS#: 119515-38-7

Chemical Formula: C12H23NO3

Exact Mass: 229.1678

Molecular Weight: 229.32

Elemental Analysis: C, 62.85; H, 10.11; N, 6.11; O, 20.93

Price and Availability

Size Price Availability Quantity
10g USD 450.00 2 Weeks
25g USD 750.00 2 Weeks
100g USD 1,250.00 2 Weeks
500g USD 2,050.00 2 Weeks
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Related CAS #
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Synonym
Icaridin; EC 423-210-8; HSDB 7374; Icaridin; Icaridina; Icaridina [INN-Spanish]; Pikaridin; Propidine; KBR 3023; KBR-3023; KBR3023.
IUPAC/Chemical Name
1-(1-Methylpropoxycarbonyl)-2-(2-hydroxyethyl)piperidine
InChi Key
QLHULAHOXSSASE-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H23NO3/c1-3-10(2)16-12(15)13-8-5-4-6-11(13)7-9-14/h10-11,14H,3-9H2,1-2H3
SMILES Code
CCC(C)OC(=O)N1CCCCC1CCO
Appearance
Oily liquid
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Picaridin (Icaridin) is a broad spectrum arthropod repellent. The repellent and deterrent activities of Picaridin involve olfactory sensing in mosquitoes, and ticks, via their interactions with odorant receptor proteins.
In vitro activity:
When the experimental data became least-squares fitted to a Hill function, as detailed in Materials and Methods, the half-maximal concentration (i.e., EC50) required for the stimulatory effect of picaridin on INa(T) or INa(L) observed in these cells was yielded as 32.7 or 2.8 μM, respectively. Overall, the data from these experiments allowed this study to ascertain that the presence of picaridin caused a stimulatory but differential effect on INa(T) and INa(L) in a concentration-dependent manner. Reference: Int J Mol Sci. 2022 Aug 26;23(17):9696. https://pubmed.ncbi.nlm.nih.gov/36077093/
In vivo activity:
Using olfactory-based choice assay this study shows here that the fruit fly is repelled by not only DEET, but also IR3535 and picaridin thus suggesting they might have "generic repellent detector(s)," which may be of practical applications in new repellent screenings. Although the ab3A neuron in the wild type flies responded to picaridin, it was unresponsive to DEET and IR3535. Reference: PLoS One. 2011 Mar 16;6(3):e17705. https://pubmed.ncbi.nlm.nih.gov/21436880/
Solvent mg/mL mM
Solubility
DMF 30.0 130.82
DMSO 137.5 599.60
Ethanol 30.0 130.82
PBS (pH 7.2) 2.0 8.72
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 229.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Shiau AL, Liao CS, Tu CW, Wu SN, Cho HY, Yu MC. Characterization in Effective Stimulation on the Magnitude, Gating, Frequency Dependence, and Hysteresis of INa Exerted by Picaridin (or Icaridin), a Known Insect Repellent. Int J Mol Sci. 2022 Aug 26;23(17):9696. doi: 10.3390/ijms23179696. PMID: 36077093; PMCID: PMC9456182. 2. Syed Z, Pelletier J, Flounders E, Chitolina RF, Leal WS. Generic insect repellent detector from the fruit fly Drosophila melanogaster. PLoS One. 2011 Mar 16;6(3):e17705. doi: 10.1371/journal.pone.0017705. PMID: 21436880; PMCID: PMC3059203.
In vitro protocol:
1. Shiau AL, Liao CS, Tu CW, Wu SN, Cho HY, Yu MC. Characterization in Effective Stimulation on the Magnitude, Gating, Frequency Dependence, and Hysteresis of INa Exerted by Picaridin (or Icaridin), a Known Insect Repellent. Int J Mol Sci. 2022 Aug 26;23(17):9696. doi: 10.3390/ijms23179696. PMID: 36077093; PMCID: PMC9456182.
In vivo protocol:
1. Syed Z, Pelletier J, Flounders E, Chitolina RF, Leal WS. Generic insect repellent detector from the fruit fly Drosophila melanogaster. PLoS One. 2011 Mar 16;6(3):e17705. doi: 10.1371/journal.pone.0017705. PMID: 21436880; PMCID: PMC3059203.
1: Boevé JL, Eertmans F, Adriaens E, Rossel B. Field Method for Testing Repellency of an Icaridin-Containing Skin Lotion against Vespid Wasps. Insects. 2016 Jun 3;7(2). pii: E22. doi: 10.3390/insects7020022. PubMed PMID: 27271672; PubMed Central PMCID: PMC4931434. 2: Abdel-Ghaffar F, Al-Quraishy S, Mehlhorn H. Length of tick repellency depends on formulation of the repellent compound (icaridin = Saltidin®): tests on Ixodes persulcatus and Ixodes ricinus placed on hands and clothes. Parasitol Res. 2015 Aug;114(8):3041-5. doi: 10.1007/s00436-015-4506-z. Epub 2015 May 9. PubMed PMID: 25952705. 3: Büchel K, Bendin J, Gharbi A, Rahlenbeck S, Dautel H. Repellent efficacy of DEET, Icaridin, and EBAAP against Ixodes ricinus and Ixodes scapularis nymphs (Acari, Ixodidae). Ticks Tick Borne Dis. 2015 Jun;6(4):494-8. doi: 10.1016/j.ttbdis.2015.03.019. Epub 2015 Apr 30. PubMed PMID: 25936273.

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