LX-1031 is a THP inhibitor (a tryptophan 5-hydroxylase inhibitor) that reduces 5-HT levels for the potential treatment of irritable bowel syndrome. LX-1031 has potential for illnesses characterized by excess 5-HT, such as diarrhea-predominant irritable bowel syndrome (IBS-D) and carcinoid diarrhea. In vitro, inhibition of TPH1 occurred in 10(-8) -10(-7) mol L(-1) range. In vivo in rodents, LX-1031 has no effect on brain 5-HT while dose-dependently reducing 5-HT, particularly in the small bowel.
MedKoo Cat#: 526775
Name: LX-1031
CAS#: 945976-76-1
Chemical Formula: C28H25F3N4O4
Exact Mass: 538.1828
Molecular Weight: 538.53
Elemental Analysis: C, 62.45; H, 4.68; F, 10.58; N, 10.40; O, 11.88
The following data is based on the product molecular weight 538.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
