GSK-625433 | CAS#885264-71-1 | HCV Polymerase Inhibitor

MedKoo Cat#: 525230 | Name: GSK-625433

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK-625433 is a homochiral inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase. This compound has the ability to inhibit the polymerase of both HCV genotypes 1a and 1b.

Chemical Structure

GSK-625433

CAS#885264-71-1

Theoretical Analysis

MedKoo Cat#: 525230

Name: GSK-625433

CAS#: 885264-71-1

Chemical Formula: C26H32N4O5S

Exact Mass: 512.2093

Molecular Weight: 512.62

Elemental Analysis: C, 60.92; H, 6.29; N, 10.93; O, 15.61; S, 6.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GSK-625433; GSK 625433; GSK625433.

IUPAC/Chemical Name

D-Proline, 1-(4-(1,1-dimethylethyl)-3-methoxybenzoyl)-4-(methoxymethyl)-2-(1H-pyrazol-1-ylmethyl)-5-(2-thiazolyl)-, (4R,5S)-rel-

InChi Key

HLQXYDHLDZTWDW-JCWFFFCVSA-N

InChi Code

InChI=1S/C26H32N4O5S/c1-25(2,3)19-8-7-17(13-20(19)35-5)23(31)30-21(22-27-10-12-36-22)18(15-34-4)14-26(30,24(32)33)16-29-11-6-9-28-29/h6-13,18,21H,14-16H2,1-5H3,(H,32,33)/t18-,21-,26-/m0/s1

SMILES Code

O=C(O)[C@]1(CN2N=CC=C2)N(C(C3=CC=C(C(C)(C)C)C(OC)=C3)=O)[C@H](C4=NC=CS4)[C@H](COC)C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 512.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Maynard A, Crosby RM, Ellis B, Hamatake R, Hong Z, Johns BA, Kahler KM, Koble C, Leivers A, Leivers MR, Mathis A, Peat AJ, Pouliot JJ, Roberts CD, Samano V, Schmidt RM, Smith GK, Spaltenstein A, Stewart EL, Thommes P, Turner EM, Voitenleitner C, Walker JT, Waitt G, Weatherhead J, Weaver K, Williams S, Wright L, Xiong ZZ, Haigh D, Shotwell JB. Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase. J Med Chem. 2014 Mar 13;57(5):1902-13. doi: 10.1021/jm400317w. Epub 2013 May 29. PubMed PMID: 23672667. 2: Rigopoulou EI, Abbott WG, Haigh P, Naoumov NV. Blocking of interleukin-10 receptor--a novel approach to stimulate T-helper cell type 1 responses to hepatitis C virus. Clin Immunol. 2005 Oct;117(1):57-64. PubMed PMID: 16006191. 3: Abbott WG, Rigopoulou E, Haigh P, Cooksley H, Mullerova I, Novelli M, Winstanley A, Williams R, Naoumov NV. Single nucleotide polymorphisms in the interferon-gamma and interleukin-10 genes do not influence chronic hepatitis C severity or T-cell reactivity to hepatitis C virus. Liver Int. 2004 Apr;24(2):90-7. PubMed PMID: 15078471.