MedKoo Cat#: 525172 | Name: Glybuzole

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Glybuzole is a sulfonamide derivative with antihyperglycemic activity. Glybuzole is able to lower blood glucose levels by increasing the release of insulin from pancreatic beta cells.

Chemical Structure

Glybuzole
Glybuzole
CAS#1492-02-0

Theoretical Analysis

MedKoo Cat#: 525172

Name: Glybuzole

CAS#: 1492-02-0

Chemical Formula: C12H15N3O2S2

Exact Mass: 297.0606

Molecular Weight: 297.40

Elemental Analysis: C, 48.46; H, 5.08; N, 14.13; O, 10.76; S, 21.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Glybuzole; Desaglybuzole; Sulfamidothiodiazol; Gludiase; Glybuzole [INN:JAN]; Glybuzolum.
IUPAC/Chemical Name
2-Benzenesulfonamido-5-tert-butyl-1,3,4-thiadiazole
InChi Key
NMWQEPCLNXHPDX-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H15N3O2S2/c1-12(2,3)10-13-14-11(18-10)15-19(16,17)9-7-5-4-6-8-9/h4-8H,1-3H3,(H,14,15)
SMILES Code
n1c(NS(=O)(=O)c2ccccc2)sc(C(C)(C)C)n1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 297.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Otsuka M, Ofusa T, Matsuda Y. Physicochemical characterization of glybuzole polymorphs and their pharmaceutical properties. Drug Dev Ind Pharm. 1999 Feb;25(2):197-203. PubMed PMID: 10065353. 2: Ishi A, Oishi T, Endo M, Mineura K. [Metabolism of glybuzole(2-benzenesulfonamido-5-tert-butyl-1-thia-3,4-diazole) in rats after pretreatment of phenobarbital, SKF 525A and carbon tetrachloride (author's transl)]. Yakugaku Zasshi. 1978 Sep;98(9):1208-14. Japanese. PubMed PMID: 731392. 3: Tamura T. [Death caused by intravenous anesthetics; thoracic pain caused by synthetic penicillin; and liver diseases induced by Glybuzole sometimes used in combination with clindamycin for the treatment of diabetes by dentists in the form of self medication]. Nihon Shika Ishikai Zasshi. 1976;29(9):961-6. Japanese. PubMed PMID: 1071098.