Synonym
FR 121196; FR 121196; FR 121196.
IUPAC/Chemical Name
Piperazine, 1-acetyl-4-(((4-fluorophenyl)sulfonyl)amino)-
InChi Key
PZQKOVUNWPDCCQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H16FN3O3S/c1-10(17)15-6-8-16(9-7-15)14-20(18,19)12-4-2-11(13)3-5-12/h2-5,14H,6-9H2,1H3
SMILES Code
N1(CCN(CC1)NS(=O)(=O)c1ccc(cc1)F)C(=O)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
301.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Maeda N, Matsuoka N, Yamazaki M, Yamaguchi I. Involvement of raphe-hippocampal serotonergic and septo-hippocampal cholinergic mechanisms in the penile erection induced by FR121196, a putative cognitive enhancer. Jpn J Pharmacol. 1995 May;68(1):85-94. PubMed PMID: 7494387.
2: Yamazaki M, Matsuoka N, Maeda N, Kuratani K, Ohkubo Y, Yamaguchi I. FR121196, a potential antidementia drug, ameliorates the impaired memory of rat in the Morris water maze. J Pharmacol Exp Ther. 1995 Jan;272(1):256-63. PubMed PMID: 7815340.
3: Matsuoka N, Maeda N, Yamaguchi I, Satoh M. Possible involvement of brain somatostatin in the memory formation of rats and the cognitive enhancing action of FR121196 in passive avoidance task. Brain Res. 1994 Apr 11;642(1-2):11-9. PubMed PMID: 7913390.
4: Maeda N, Matsuoka N, Yamazaki M, Arakawa H, Ohkubo Y, Yamaguchi I. A screening concept based on a hypothesis led to the development of a putative cognitive enhancer that stimulates penile erection. Jpn J Pharmacol. 1994 Mar;64(3):147-53. PubMed PMID: 8022116.
5: Matsuoka N, Yamaguchi I, Satoh M. Role of somatostatin in the augmentation of hippocampal long-term potentiation by FR121196, a putative cognitive enhancer. Eur J Pharmacol. 1993 Sep 7;241(1):27-34. PubMed PMID: 7901036.
6: Matsuoka N, Maeda N, Yamazaki M, Ohkubo Y, Yamaguchi I. Effect of FR121196, a novel cognitive enhancer, on the memory impairment of rats in passive avoidance and radial arm maze tasks. J Pharmacol Exp Ther. 1992 Nov;263(2):436-44. PubMed PMID: 1432682.
