Clevidipine is a dihydropyridine L-type calcium channel blocker, highly selective for vascular, as opposed to myocardial, smooth muscle and, therefore, has little or no effect on myocardial contractility or cardiac conduction. It reduces mean arterial blood pressure by decreasing systemic vascular resistance. Clevidipine does not reduce cardiac filling pressure, confirming lack of effects on the venous capacitance vessels. No increase in myocardial lactate production in coronary sinus blood has been seen, confirming the absence of myocardial ischemia due to coronary steal.
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Process for preparation and purification of clevidipine butyrate and dihydropyridine intermediates thereof; Vishnu Newadkar, Ravindranath; Purushottam Joshi, Anil; Kumar Singh, Santosh Assignee Laboratorios Lesvi, S.A., Spain 2011; Patent Information; Nov 10, 2011; US 20110275825 A1
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Chen, Ji; Zhang, Ai-ming; Zhu, Xue-yan; Yuan, Zhe-dong. Synthesis of clevidipine butyrate. Zhongguo Xinyao Zazhi. Volume 21. Issue 20. Pages 2368-2370. 2012.
Zhou, Xiaoshun; Tong, Guofu; Rao, Dunyan; Peng, Mengjun; Li, Jin. Method for preparation of clevidipine butyrate. Assignee Wuhan Kefu New Drugs Co., Ltd., Peop. Rep. China. CN 103012249. (2013).
Vishnu Newadkar, Ravindranath; Purushottam Joshi, Anil; Kumar Singh, Santosh. Process for preparation and purification of clevidipine butyrate and dihydropyridine intermediates thereof. Assignee Laboratorios Lesvi, S.A., Spain. US 20110275825. (2011).
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Guo, Jingjun; Wu, Junmao; Gao, Chuanfu; Guo, Yong; Wang, Shihui; Zhang, Xiaofeng; Tian, Lina; Tian, Fengming. Process for preparation of clevidipine butyrate and intermediates thereof. Assignee Beijing Jialin Pharmaceutical Co., Ltd., Peop. Rep. China. CN 103073485. (2013).
