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MedKoo Cat#: 317541 | Name: Clevidipine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clevidipine is a dihydropyridine L-type calcium channel blocker, highly selective for vascular, as opposed to myocardial, smooth muscle and, therefore, has little or no effect on myocardial contractility or cardiac conduction. It reduces mean arterial blood pressure by decreasing systemic vascular resistance. Clevidipine does not reduce cardiac filling pressure, confirming lack of effects on the venous capacitance vessels. No increase in myocardial lactate production in coronary sinus blood has been seen, confirming the absence of myocardial ischemia due to coronary steal.

Chemical Structure

Clevidipine
Clevidipine
CAS#167221-71-8

Theoretical Analysis

MedKoo Cat#: 317541

Name: Clevidipine

CAS#: 167221-71-8

Chemical Formula: C21H23Cl2NO6

Exact Mass: 455.0900

Molecular Weight: 456.32

Elemental Analysis: C, 55.27; H, 5.08; Cl, 15.54; N, 3.07; O, 21.04

Price and Availability

Size Price Availability Quantity
100mg USD 250.00 2 Weeks
250mg USD 450.00 2 Weeks
500mg USD 750.00 2 Weeks
1g USD 1,250.00 2 Weeks
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Related CAS #
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Synonym
Clevidipine; Clevidipine butyrate; Cleviprex; Clevelox; Rac-Clevidipine;
IUPAC/Chemical Name
methyl 5-{[(butanoyloxy)methoxy]carbonyl}-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate
InChi Key
KPBZROQVTHLCDU-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H23Cl2NO6/c1-5-7-15(25)29-10-30-21(27)17-12(3)24-11(2)16(20(26)28-4)18(17)13-8-6-9-14(22)19(13)23/h6,8-9,18,24H,5,7,10H2,1-4H3
SMILES Code
CCCC(=O)OCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C
Appearance
Solid powder
Purity
>97% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 456.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhou Y, Zhou F, Yan F, Yang F, Yao Y, Zou Q. Structural Analysis and Quantitative Determination of Clevidipine Butyrate Impurities Using an Advanced RP-HPLC Method. J Chromatogr Sci. 2015 Oct 21. pii: bmv148. [Epub ahead of print] PubMed PMID: 26489435. 2: Lemkuil BP, Gierl BT, Patel PM, Pearn ML, Nguyen LC, Minokadeh A, Drummond JC. The Effect of Clevidipine on Cerebral Blood Flow Velocity and Carbon Dioxide Reactivity in Human Volunteers. J Neurosurg Anesthesiol. 2015 Oct 6. [Epub ahead of print] PubMed PMID: 26447497. 3: Zhou Y, Zou Q, Sun L, Wei P, Ouyang P. Determination of clevidipine and its primary metabolite in rat plasma by a dispersive liquid-liquid microextraction method. J Chromatogr Sci. 2015 May-Jun;53(5):830-5. doi: 10.1093/chromsci/bmu100. Epub 2014 Dec 5. PubMed PMID: 25480456. 4: Kako H, Gable A, Martin D, Beebe A, Thung A, Samora W, Klamar J, Bhalla T, Tobias JD. A prospective, open-label trial of clevidipine for controlled hypotension during posterior spinal fusion. J Pediatr Pharmacol Ther. 2015 Jan-Feb;20(1):54-60. doi: 10.5863/1551-6776-20.1.54. PubMed PMID: 25859171; PubMed Central PMCID: PMC4353201. 5: Zhou Y, He XM, Li HQ, Ni Y, Xu MZ, Chen H, Li WY. Pharmacokinetics and tissue distribution of clevidipine and its metabolite in dogs and rats. J Huazhong Univ Sci Technolog Med Sci. 2014 Dec;34(6):856-60. doi: 10.1007/s11596-014-1364-3. Epub 2014 Dec 6. PubMed PMID: 25480581. 6: Zuleta-Alarcón A, Castellón-Larios K, Bergese S. [The role of clevidipine in hypertension management: clinical results]. Rev Esp Anestesiol Reanim. 2014 Dec;61(10):557-64. doi: 10.1016/j.redar.2014.06.006. Epub 2014 Sep 16. Spanish. PubMed PMID: 25236947. 7: Wei H, Gu Y, Liu Y, Chen Y, Liu C, Si D. Quantitation of clevidipine in dog blood by liquid chromatography tandem mass spectrometry: application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Nov 15;971:52-7. doi: 10.1016/j.jchromb.2014.09.019. Epub 2014 Sep 29. PubMed PMID: 25270056. 8: Zhou Y, Li H, He X, Jia M, Ni Y, Xu M, Chen H, Li W. Simultaneous determination of clevidipine and its primary metabolite in dog plasma by liquid chromatography-tandem mass spectrometry: Application to pharmacokinetic study. J Pharm Biomed Anal. 2014 Nov;100:294-9. doi: 10.1016/j.jpba.2014.08.018. Epub 2014 Aug 17. PubMed PMID: 25194342. 9: Cao P, Li G, Huang L, Zhao S, Hu Y, Qin L, Qiu L, Zhu W, Si L, Huang J. Screening of stabilizers for LC-MS/MS analysis of clevidipine and its primary metabolite in dog whole blood. Bioanalysis. 2015;7(12):1457-69. doi: 10.4155/bio.15.74. PubMed PMID: 26168253. 10: Clevidipine. Hypertensive crises during surgery: no advance. Prescrire Int. 2014 Oct;23(153):236. PubMed PMID: 25964966. 11: Keating GM. Clevidipine: a review of its use for managing blood pressure in perioperative and intensive care settings. Drugs. 2014 Oct;74(16):1947-60. doi: 10.1007/s40265-014-0313-6. Review. PubMed PMID: 25312594. 12: Croft K, Probst S. Deliberate hypotensive anesthesia with the rapidly acting, vascular-selective, L-type calcium channel antagonist-clevidipine: a case report. Anesth Prog. 2014 Spring;61(1):18-20. doi: 10.2344/0003-3006-61.1.18. PubMed PMID: 24697821; PubMed Central PMCID: PMC3975609. 13: Varelas PN, Abdelhak T, Corry JJ, James E, Rehman MF, Schultz L, Mays-Wilson K, Mitsias P. Clevidipine for acute hypertension in patients with subarachnoid hemorrhage: a pilot study. Int J Neurosci. 2014 Mar;124(3):192-8. doi: 10.3109/00207454.2013.836703. Epub 2013 Sep 24. PubMed PMID: 24007334. 14: Merry AF, Avery EG, Nussmeier NA, Playford HR, Warman GR, Wang Y, Sladen RN. Clevidipine compared with nitroglycerin for blood pressure control in coronary artery bypass grafting: a randomized double-blind study. Can J Anaesth. 2014 May;61(5):398-406. doi: 10.1007/s12630-014-0131-z. Epub 2014 Apr 4. PubMed PMID: 24700403. 15: Peacock WF, Chandra A, Char D, Collins S, Der Sahakian G, Ding L, Dunbar L, Fermann G, Fonarow GC, Garrison N, Hu MY, Jourdain P, Laribi S, Levy P, Möckel M, Mueller C, Ray P, Singer A, Ventura H, Weiss M, Mebazaa A. Clevidipine in acute heart failure: Results of the A Study of Blood Pressure Control in Acute Heart Failure-A Pilot Study (PRONTO). Am Heart J. 2014 Apr;167(4):529-36. doi: 10.1016/j.ahj.2013.12.023. Epub 2014 Jan 15. PubMed PMID: 24655702. 16: Kurnutala LN, Soghomonyan S, Bergese SD. Perioperative acute hypertension-role of Clevidipine butyrate. Front Pharmacol. 2014 Aug 27;5:197. doi: 10.3389/fphar.2014.00197. eCollection 2014. PubMed PMID: 25221513; PubMed Central PMCID: PMC4145348. 17: Bettesworth JG, Martin DP, Tobias JD. Intraoperative use of clevidipine in a patient with von Hippel-Lindau disease with associated pheochromocytoma. J Cardiothorac Vasc Anesth. 2013 Aug;27(4):749-51. doi: 10.1053/j.jvca.2011.12.005. Epub 2012 Feb 1. PubMed PMID: 22305918. 18: Hassanain HH, Hassona MD, Puente EG, Sun C, Abouelnaga ZA, Tulman DB, Bergese SD. In vitro assessment of clevidipine using the profilin1 hypertensive mouse model. Pharmaceuticals (Basel). 2013 Apr 29;6(5):623-33. doi: 10.3390/ph6050623. PubMed PMID: 24276170; PubMed Central PMCID: PMC3817727. 19: Tobias JD, Tulman DB, Bergese SD. Clevidipine for perioperative blood pressure control in infants and children. Pharmaceuticals (Basel). 2013 Jan 15;6(1):70-84. doi: 10.3390/ph6010070. PubMed PMID: 24275788; PubMed Central PMCID: PMC3816677. 20: Graffagnino C, Bergese S, Love J, Schneider D, Lazaridis C, LaPointe M, Lee K, Lynch G, Hu MY, Williams GC. Clevidipine rapidly and safely reduces blood pressure in acute intracerebral hemorrhage: the ACCELERATE trial. Cerebrovasc Dis. 2013;36(3):173-80. doi: 10.1159/000351149. Epub 2013 Oct 12. PubMed PMID: 24135526.