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MedKoo Cat#: 525040 | Name: FE-999024 free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FE-999024 is a selective inhibitor of tissue kallikrein. FE999026 significantly inhibited plasma kallikrein-like activity in the pancreas.

Chemical Structure

FE-999024 free base
FE-999024 free base
CAS#168825-65-8

Theoretical Analysis

MedKoo Cat#: 525040

Name: FE-999024 free base

CAS#: 168825-65-8

Chemical Formula: C26H31ClN6O2

Exact Mass: 494.2197

Molecular Weight: 495.02

Elemental Analysis: C, 63.08; H, 6.31; Cl, 7.16; N, 16.98; O, 6.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
FE-999024; FE 999024; FE999024; CH-2856; CH2856; CH 2856;
IUPAC/Chemical Name
(R)-2-amino-N-((S)-1-amino-3-(naphthalen-1-yl)-1-oxopropan-2-yl)-3-(4-chlorophenyl)-N-(3-guanidinopropyl)propanamide
InChi Key
IMGYACQIHRRBMK-PKTZIBPZSA-N
InChi Code
InChI=1S/C26H31ClN6O2/c27-20-11-9-17(10-12-20)15-22(28)25(35)33(14-4-13-32-26(30)31)23(24(29)34)16-19-7-3-6-18-5-1-2-8-21(18)19/h1-3,5-12,22-23H,4,13-16,28H2,(H2,29,34)(H4,30,31,32)/t22-,23+/m1/s1
SMILES Code
O=C(N)[C@H](CC1=C2C=CC=CC2=CC=C1)N(C([C@H](N)CC3=CC=C(C=C3)Cl)=O)CCCNC(N)=N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 495.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Broadley KJ, Blair AE, Kidd EJ, Bugert JJ, Ford WR. Bradykinin-induced lung inflammation and bronchoconstriction: role in parainfluenze-3 virus-induced inflammation and airway hyperreactivity. J Pharmacol Exp Ther. 2010 Dec;335(3):681-92. doi: 10.1124/jpet.110.171876. Epub 2010 Sep 16. PubMed PMID: 20847038. 2: Griesbacher T, Rainer I, Tiran B, Evans DM. Involvement of tissue kallikrein but not plasma kallikrein in the development of symptoms mediated by endogenous kinins in acute pancreatitis in rats. Br J Pharmacol. 2002 Nov;137(5):692-700. PubMed PMID: 12381683; PubMed Central PMCID: PMC1573532. 3: Wolf WC, Evans DM, Chao L, Chao J. A synthetic tissue kallikrein inhibitor suppresses cancer cell invasiveness. Am J Pathol. 2001 Nov;159(5):1797-805. PubMed PMID: 11696440; PubMed Central PMCID: PMC1867063.