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MedKoo Cat#: 525750 | Name: Niclofolan

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Niclofolan is a biphenyl anthelmintic compound. Niclofolan is used orally towards the treatment of Fasciola hepatica infection. Niclofolan therapy achieved elimination of eggs from the feces and normalization of eosinophil counts, liver enzymes and Fasciola titers, suggesting eradication of biliary flukes.

Chemical Structure

Niclofolan
Niclofolan
CAS#10331-57-4

Theoretical Analysis

MedKoo Cat#: 525750

Name: Niclofolan

CAS#: 10331-57-4

Chemical Formula: C12H6Cl2N2O6

Exact Mass: 343.9603

Molecular Weight: 345.09

Elemental Analysis: C, 41.77; H, 1.75; Cl, 20.55; N, 8.12; O, 27.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Menichlopholan; Niclofolan; Niclofolano; Niclofolanum; Bilevon M; ME-3625; ME3625; ME 3625; BAY9015; BAY-9015; BAY 9015; Niclofolan
IUPAC/Chemical Name
6,6'-dichloro-4,4'-dinitro-[1,1'-biphenyl]-2,2'-diol
InChi Key
AFERZLYRSYSCMW-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H6Cl2N2O6/c13-7-1-5(15(19)20)3-9(17)11(7)12-8(14)2-6(16(21)22)4-10(12)18/h1-4,17-18H
SMILES Code
OC1=CC([N+]([O-])=O)=CC(Cl)=C1C2=C(Cl)C=C([N+]([O-])=O)C=C2O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 345.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ali BH, el Sheikh HA, McKellar QA. Pharmacokinetics of niclofolan in desert sheep. J Vet Pharmacol Ther. 1990 Jun;13(2):217-9. PubMed PMID: 2384912. 2: Ali BH, Hassan T, Haroun EM, Abu Samra MT. The effect of niclofolan on desert sheep experimentally infected with immature Fasciola gigantica. J Vet Pharmacol Ther. 1985 Dec;8(4):398-403. PubMed PMID: 4094030. 3: Güralp N, Tinar R. Trematodiasis in Turkey: comparative efficacy of triclabendazole and niclofolan against natural infections of Fasciola hepatica and F. gigantica in sheep. J Helminthol. 1984 Jun;58(2):113-6. PubMed PMID: 6747253. 4: González H, Plaza J, Montes G, Pérez R, Toro P. [Anthelmintic activity of niclofolan and closantel against Fasciola hepatica in sheep]. Bol Chil Parasitol. 1983 Jul-Dec;38(3-4):42-9. Spanish. PubMed PMID: 6375690. 5: Reshef R, Lok AS, Sherlock S. Cholestatic jaundice in fascioliasis treated with niclofolan. Br Med J (Clin Res Ed). 1982 Oct 30;285(6350):1243-4. PubMed PMID: 6812826; PubMed Central PMCID: PMC1499778. 6: Hong ST, Lee SH, Ahn HS, Yun CK. A Case Of Niclofolan (Bilevon(R)) Intoxication. Kisaengchunghak Chapchi. 1982 Jun;20(1):49-52. PubMed PMID: 12902700. 7: Eckhardt T, Heckers H. Treatment of human fascioliasis with niclofolan. Gastroenterology. 1981 Oct;81(4):795-8. PubMed PMID: 7262525. 8: Ripert C, Carrie J, Ambroise-Thomas P, Baecher R, Kum NP, Same-Ekobo A. [Epidemiologic and clinical study of paragonimosis in Cameroon. Results of niclofolan treatment]. Bull Soc Pathol Exot Filiales. 1981 May-Jun;74(3):319-31. French. PubMed PMID: 7285268. 9: Bunnag D, Harinasuta T, Desakorn V. Studies on the chemotherapy of human opisthorchiasis: II. Clinical trial of niclofolan. Southeast Asian J Trop Med Public Health. 1981 Mar;12(1):107-9. PubMed PMID: 7020093. 10: Cao WJ. [Preliminary observation on the treatment of paragonimiasis westermani (thoracic type) with domestic niclofolan in 26 cases (author's transl)]. Zhonghua Nei Ke Za Zhi. 1980 May;19(3):226-9. Chinese. PubMed PMID: 7227061. 11: Ambroise-Thomas P, Wegner DH, Goullier A, Desgeorges PT, Billiault X. [Clinical trial of niclofolan (Bay 9015) in the treatment of human opisthorchiasis. Apropos of 51 cases]. Bull Soc Pathol Exot Filiales. 1980 May-Jun;73(3):293-301. French. PubMed PMID: 7014011. 12: Rim HJ, Kim MS, Ha JH, Chang DS. Expermental chemotherapeutic effects of niclofolan (Bayer 9015, Bilevon) on the animals infected with Paragonimus westermani or P. iloktsuenensis. Kisaengchunghak Chapchi. 1976 Dec;14(2):140-146. PubMed PMID: 12913443. 13: Ueno H, Morales GL. Fasciolicidal activity of diamphenethide and niclofolan against Fasciola hepatica in sheep in the Altiplano region of Bolivia. Natl Inst Anim Health Q (Tokyo). 1973 Summer;13(2):75-9. PubMed PMID: 4792403. 14: Ueno H, Alvarez JM, De Mergen AM, Cabral AF, Bodden HA. Field trials with rafoxanide, bithionol sulfoxide and niclofolan against Fasciola hepatica in cattle in the dominican republic. Natl Inst Anim Health Q (Tokyo). 1973 Summer;13(2):69-74. PubMed PMID: 4792402.