BAY65-1942 free base | CAS#600734-02-9 | IKKβ kinase inhibitor

MedKoo Cat#: 406773 | Name: BAY65-1942 free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BAY65-1942 is an ATP-competitive inhibitor that selectively targets IKKbeta kinase activity. IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury.

Chemical Structure

BAY65-1942 free base

CAS#600734-02-9

Theoretical Analysis

MedKoo Cat#: 406773

Name: BAY65-1942 free base

CAS#: 600734-02-9

Chemical Formula: C22H25N3O4

Exact Mass: 395.1845

Molecular Weight: 395.46

Elemental Analysis: C, 66.82; H, 6.37; N, 10.63; O, 16.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

BAY 65-1942; BAY-65-1942; BAY65-1942; BAY 651942; BAY-651942; BAY651942. BAY65-1942 free base.

IUPAC/Chemical Name

(S)-7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(piperidin-3-yl)-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one

InChi Key

IGJVFGZEWDGDOO-CQSZACIVSA-N

InChi Code

InChI=1S/C22H25N3O4/c26-18-4-1-5-19(28-11-13-6-7-13)20(18)17-9-15(14-3-2-8-23-10-14)16-12-29-22(27)25-21(16)24-17/h1,4-5,9,13-14,23,26H,2-3,6-8,10-12H2,(H,24,25,27)/t14-/m1/s1

SMILES Code

OC(C=CC=C1OCC2CC2)=C1C3=NC4=C(COC(N4)=O)C([C@H]5CNCCC5)=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 395.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Cooper MJ, Cox NJ, Zimmerman EI, Dewar BJ, Duncan JS, Whittle MC, Nguyen TA, Jones LS, Ghose Roy S, Smalley DM, Kuan PF, Richards KL, Christopherson RI, Jin J, Frye SV, Johnson GL, Baldwin AS, Graves LM. Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia. PLoS One. 2013 Jun 24;8(6):e66755. doi: 10.1371/journal.pone.0066755. Print 2013. PubMed PMID: 23826126; PubMed Central PMCID: PMC3691232. 2: Harken AH. The world of inhibitory kappaB. Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2624-5. Epub 2007 Sep 7. PubMed PMID: 17827258. 3: Moss NC, Stansfield WE, Willis MS, Tang RH, Selzman CH. IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2248-53. Epub 2007 Aug 3. PubMed PMID: 17675566.