Synonym
NITD-304; NITD 304; NITD304.
IUPAC/Chemical Name
4,6-dichloro-N-(4,4-dimethylcyclohexyl)-1H-indole-2-carboxamide
InChi Key
NKNGAORFGPSYJG-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H20Cl2N2O/c1-17(2)5-3-11(4-6-17)20-16(22)15-9-12-13(19)7-10(18)8-14(12)21-15/h7-9,11,21H,3-6H2,1-2H3,(H,20,22)
SMILES Code
O=C(C(N1)=CC2=C1C=C(Cl)C=C2Cl)NC3CCC(C)(C)CC3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Note: chemical structure was from
Indole-2-carboxamide-based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection
Jozef Stec, Oluseye K. Onajole, Shichun Lun, Haidan Guo, Benjamin Merenbloom, Giulio Vistoli, William R. Bishai, and Alan P. Kozikowski
Publication Date (Web): June 8, 2016 (Article)
DOI: 10.1021/acs.jmedchem.6b00415
Preparing Stock Solutions
The following data is based on the
product
molecular weight
339.26
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Rao SP, Lakshminarayana SB, Kondreddi RR, Herve M, Camacho LR, Bifani P,
Kalapala SK, Jiricek J, Ma NL, Tan BH, Ng SH, Nanjundappa M, Ravindran S, Seah
PG, Thayalan P, Lim SH, Lee BH, Goh A, Barnes WS, Chen Z, Gagaring K, Chatterjee
AK, Pethe K, Kuhen K, Walker J, Feng G, Babu S, Zhang L, Blasco F, Beer D, Weaver
M, Dartois V, Glynne R, Dick T, Smith PW, Diagana TT, Manjunatha UH.
Indolcarboxamide is a preclinical candidate for treating multidrug-resistant
tuberculosis. Sci Transl Med. 2013 Dec 4;5(214):214ra168. doi:
10.1126/scitranslmed.3007355. PubMed PMID: 24307692.
