Related CAS #
24886-52-0 (free base); 24853-80-3 (HCl)
Synonym
Azaphen HCl; Azafen; Pipofezine; Pipofezine HCl
IUPAC/Chemical Name
5-methyl-3-(4-methylpiperazin-1-yl)pyridazino[3,4-b][1,4]benzoxazine hydrochloride.
InChi Key
JVONTAXIALFQJM-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H19N5O.ClH/c1-19-7-9-21(10-8-19)15-11-13-16(18-17-15)22-14-6-4-3-5-12(14)20(13)2;/h3-6,11H,7-10H2,1-2H3;1H
SMILES Code
CN1CCN(C2=NN=C3OC4=CC=CC=C4N(C)C3=C2)CC1.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
333.82
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Shinaev NN, Akzhigitov RG. [Azaphen: a return to clinical practice]. Zh Nevrol Psikhiatr Im S S Korsakova. 2005;105(10):55-6. Russian. PubMed PMID: 16281382.
2: Ignatowicz L, Ignatowicz R, Wdowiak MW, Jaremko A. [Azaphen in the treatment of enuresis in children]. Psychiatr Pol. 1977 Jan-Feb;11(1):29-33. Polish. PubMed PMID: 557800.
3: Liberman SS, Sharova SA. [A comparison of the effect of the tricyclic antidepressants azaphen and imizin on the gastrointestinal tracts of experimental animals]. Farmakol Toksikol. 1975 Jan-Feb;38(1):29-32. Russian. PubMed PMID: 1112390.
4: Misurec J, Náhunek K, Kamenická V, Chmelar M. Proceedings: Influence of azaphen, a new antidepressive drug, on the human EEG. Act Nerv Super (Praha). 1974;16(4):245-6. PubMed PMID: 4450998.
5: Siniukhin VN. [Absorption and organ distribution of the new antidepressant azaphen]. Farmakol Toksikol. 1973 Jul-Aug;26(4):409-11. Russian. PubMed PMID: 4789881.
6: Andreeva NI. [Effect of the tricyclic antidepressants--imizin, desipramine, amitryptyline and azaphen on gastric secretion in rats]. Farmakol Toksikol. 1972 Jul;35(4):443-5. Russian. PubMed PMID: 5050274.
7: Roshchina LF. [Effect of azaphen on conditioned avoidance reflex in rats]. Farmakol Toksikol. 1971 Nov-Dec;34(6):643-6. Russian. PubMed PMID: 5139777.
8: Kutchak SN, Sharova SA, Egorova EF. [Toxicological study of azaphen]. Farmakol Toksikol. 1971 May-Jun;34(3):291-2. Russian. PubMed PMID: 5568686.
9: Mashkovskiĭ MD, Roshchina LF. [Effect of azaphen on the bioelectric activity of the brain]. Farmakol Toksikol. 1971;34(2):144-8. Russian. PubMed PMID: 5563383.
10: Mashkovskiĭ MD, Polezhaeva AI. [Pharmacological properties of new antidepressive agent azaphen]. Farmakol Toksikol. 1969 Nov-Dec;32(6):656-62. Russian. PubMed PMID: 5381594.
11: Mashkovskii MD, Polezhaeva AI, Avrutskii GIa, Vertozgadova OP, Smulevich AB. [The pharmacologic properties and therapeutic effectiveness of the new antidepressant preparation Azaphen]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1969;69(8):1234-8. Russian. PubMed PMID: 5392529.
