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MedKoo Cat#: 524867 | Name: CP-690550A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CP-690550A is a novel JAK3 inhibitor, an immunosuppressant for the treatment of rheumatoid arthritis, transplant rejection, psoriasis and other immune-mediated disorders.

Chemical Structure

CP-690550A
CP-690550A
CAS#1243290-37-0

Theoretical Analysis

MedKoo Cat#: 524867

Name: CP-690550A

CAS#: 1243290-37-0

Chemical Formula: C15H21N5O2

Exact Mass: 303.1695

Molecular Weight: 303.36

Elemental Analysis: C, 59.39; H, 6.98; N, 23.09; O, 10.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CP-690550A; CP-690,550A; CP 690550A; CP690550A; Tofacitinib metabolite M2; UNII-Q7ZOK859UK.
IUPAC/Chemical Name
2-Hydroxy-1-(4-methyl-3-(methyl-(7hpyrrolo(2,3-d)pyrimidin-4-yl)-amino)-piperidin-1-yl)-ethanone
InChi Key
CCOHWQFOFWCBMH-PWSUYJOCSA-N
InChi Code
InChI=1S/C15H21N5O2/c1-10-4-6-20(13(22)8-21)7-12(10)19(2)15-11-3-5-16-14(11)17-9-18-15/h3,5,9-10,12,21H,4,6-8H2,1-2H3,(H,16,17,18)/t10-,12+/m1/s1
SMILES Code
C[C@@H]1CCN(C[C@@H]1N(C)c2c3cc[nH]c3ncn2)C(=O)CO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 303.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Tofacitinib for the treatment of psoriasis. Expert Opin Pharmacother. 2016 Jul;17(10):1421-33. doi: 10.1080/14656566.2016.1195812. PubMed PMID: 27267933. 9: Damsky WE, Choi J. Genetics of Cutaneous T Cell Lymphoma: From Bench to Bedside. Curr Treat Options Oncol. 2016 Jul;17(7):33. doi: 10.1007/s11864-016-0410-8. Review. PubMed PMID: 27262707. 10: Iwata S, Tanaka Y. Progress in understanding the safety and efficacy of Janus kinase inhibitors for treatment of rheumatoid arthritis. Expert Rev Clin Immunol. 2016 Jun 6:1-11. [Epub ahead of print] PubMed PMID: 27253519. 11: Tran CT, Ducancelle A, Masson C, Lunel-Fabiani F. Herpes zoster: Risk and prevention during immunomodulating therapy. Joint Bone Spine. 2016 May 27. pii: S1297-319X(16)30052-5. doi: 10.1016/j.jbspin.2016.04.001. [Epub ahead of print] PubMed PMID: 27245419. 12: Xie F, Yun H, Bernatsky S, Curtis JR. Risk for Gastrointestinal Perforation among Rheumatoid Arthritis Patients receiving Tofacitinib, Tocilizumab, or other Biologics. Arthritis Rheumatol. 2016 May 23. doi: 10.1002/art.39761. [Epub ahead of print] PubMed PMID: 27213279. 13: Anzengruber F, Maul JT, Kamarachev J, Trüeb RM, French LE, Navarini AA. Transient Efficacy of Tofacitinib in Alopecia Areata Universalis. Case Rep Dermatol. 2016 Apr 22;8(1):102-6. doi: 10.1159/000445182. eCollection 2016 Jan-Apr. PubMed PMID: 27194979; PubMed Central PMCID: PMC4869306. 14: Panés J, Su C, Bushmakin AG, Cappelleri JC, Healey P. Direct and Indirect Effects of Tofacitinib on Treatment Satisfaction in Patients with Ulcerative Colitis. J Crohns Colitis. 2016 May 18. pii: jjw107. [Epub ahead of print] PubMed PMID: 27194530. 15: Yamaoka K. Benefit and Risk of Tofacitinib in the Treatment of Rheumatoid Arthritis: A Focus on Herpes Zoster. Drug Saf. 2016 May 18. [Epub ahead of print] Review. PubMed PMID: 27193610. 16: Louder AM, Singh A, Saverno K, Cappelleri JC, Aten AJ, Koenig AS, Pasquale MK. Patient Preferences Regarding Rheumatoid Arthritis Therapies: A Conjoint Analysis. Am Health Drug Benefits. 2016 Apr;9(2):84-93. PubMed PMID: 27182427; PubMed Central PMCID: PMC4856233. 17: Izzo R, Bevivino G, Monteleone G. Tofacitinib for the treatment of ulcerative colitis. Expert Opin Investig Drugs. 2016 May 30:1-7. [Epub ahead of print] PubMed PMID: 27177233. 18: Singh JA, Hossain A, Tanjong Ghogomu E, Kotb A, Christensen R, Mudano AS, Maxwell LJ, Shah NP, Tugwell P, Wells GA. Biologics or tofacitinib for rheumatoid arthritis in incomplete responders to methotrexate or other traditional disease-modifying anti-rheumatic drugs: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2016 May 13;(5):CD012183. doi: 10.1002/14651858.CD012183. Review. PubMed PMID: 27175934. 19: Piscianz E, Candilera V, Valencic E, Loganes C, Paron G, De Iudicibus S, Decorti G, Tommasini A. Action of methotrexate and tofacitinib on directly stimulated and bystander-activated lymphocytes. Mol Med Rep. 2016 Jul;14(1):574-82. doi: 10.3892/mmr.2016.5263. Epub 2016 May 13. PubMed PMID: 27175898. 20: Fleischmann R, Strand V, Wilkinson B, Kwok K, Bananis E. Relationship between clinical and patient-reported outcomes in a phase 3 trial of tofacitinib or MTX in MTX-naïve patients with rheumatoid arthritis. RMD Open. 2016 Apr 26;2(1):e000232. doi: 10.1136/rmdopen-2015-000232. eCollection 2016. PubMed PMID: 27175296; PubMed Central PMCID: PMC4860866.