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MedKoo Cat#: 524862 | Name: CP-66,948

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CP-66,948 is a histamine H2-receptor antagonist with gastric antisecretory activity and mucosal protective properties. The affinity of CP-66,948 for the guinea pig atria histamine H2-receptor is 15 times greater than that of cimetidine and seven times greater than that of ranitidine. In vivo, the ED50 value for inhibition of gastric acid secretion in pylorus-ligated rats is 2 mg/kg intraduodenally.

Chemical Structure

CP-66,948
CP-66,948
CAS#101189-47-3

Theoretical Analysis

MedKoo Cat#: 524862

Name: CP-66,948

CAS#: 101189-47-3

Chemical Formula: C13H20N6S

Exact Mass: 292.1470

Molecular Weight: 292.40

Elemental Analysis: C, 53.40; H, 6.89; N, 28.74; S, 10.97

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CP66,948; CP 66,948; CP-66,948; CP 66948.
IUPAC/Chemical Name
2-(N-Pentyl-N''-guanidino)-4-(2-methylimidazol-4-yl)thiazole
InChi Key
OZSXWXGDJLBJQO-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H20N6S/c1-3-4-5-6-15-12(14)19-13-18-11(8-20-13)10-7-16-9(2)17-10/h7-8H,3-6H2,1-2H3,(H,16,17)(H3,14,15,18,19)
SMILES Code
CCCCCNC(=N)Nc1scc(n1)c1cnc([nH]1)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 292.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hakkinen JP, Holt WF, Goddard CJ, Oates PJ, Murphy WR, Maciejko JJ, Reiter LA. CP-66,948: an antisecretory histamine H2-receptor antagonist with mucosal protective properties. Dig Dis Sci. 1991 Dec;36(12):1721-8. PubMed PMID: 1748041.