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MedKoo Cat#: 524854 | Name: CP-5609

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CP-5609 is a novel carbapenem with enhanced antimicrobial activities.

Chemical Structure

CP-5609
CP-5609
CAS#432038-96-5

Theoretical Analysis

MedKoo Cat#: 524854

Name: CP-5609

CAS#: 432038-96-5

Chemical Formula: C23H21N5O6S

Exact Mass: 495.1213

Molecular Weight: 495.51

Elemental Analysis: C, 55.75; H, 4.27; N, 14.13; O, 19.37; S, 6.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CP-5609; CP 5609; CP5609; ME-1036; ME 1036;ME1036; UNII-33501R83O2.
IUPAC/Chemical Name
Pyridinium, 1-(2-amino-2-oxoethyl)-3-((2-((4S,5R,6S)-2-carboxy-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-en-3-yl)imidazo(5,1-b)thiazol-7-yl)carbonyl)-, inner salt
InChi Key
LZKPUSJSJVEXAW-WDXSGGTDSA-N
InChi Code
InChI=1S/C23H21N5O6S/c1-10-15(19(23(33)34)28-18(10)16(11(2)29)21(28)32)13-7-27-9-25-17(22(27)35-13)20(31)12-4-3-5-26(6-12)8-14(24)30/h3-7,9-11,16,18,29H,8H2,1-2H3,(H2-,24,30,33,34)/t10-,11+,16+,18+/m0/s1
SMILES Code
C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1c3cn4cnc(c4s3)C(=O)c5ccc[n+](c5)CC(=O)N)C(=O)[O-])[C@@H](C)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 495.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hirai Y, Takahata S, Yamada K, Ida T, Maebashi K. Correlation of the antimicrobial activity of ME1036 with its binding affinities to the penicillin-binding proteins from Streptococcus pneumoniae strains. J Antibiot (Tokyo). 2011 Nov;64(11):741-6. doi: 10.1038/ja.2011.76. Epub 2011 Aug 24. PubMed PMID: 21863036. 2: Morrissey I, Biek D, Janes R. ME1036, a novel carbapenem, with enhanced activity against clinical isolates causing bacteraemic community-acquired pneumonia. J Antimicrob Chemother. 2009 Jul;64(1):209-10. doi: 10.1093/jac/dkp163. Epub 2009 May 9. PubMed PMID: 19429928. 3: Yanagihara K, Ohnishi Y, Morinaga Y, Nakamura S, Kurihara S, Seki M, Izumikawa K, Kakeya H, Yamamoto Y, Yamada Y, Kohno S, Kamihira S. Efficacy of ME1036 against meticillin-resistant Staphylococcus aureus and vancomycin-insensitive S. aureus in a model of haematogenous pulmonary infection. Int J Antimicrob Agents. 2008 Nov;32(5):401-4. doi: 10.1016/j.ijantimicag.2008.04.030. Epub 2008 Aug 19. PubMed PMID: 18715761. 4: Fenoll A, Aguilar L, Robledo O, Giménez MJ, Granizo JJ, Biek D, Tarragó D. In vitro activity of ME1036 versus other beta-lactams against penicillin-resistant Streptococcus pneumoniae serotypes exhibiting higher amoxicillin than penicillin MIC. J Antimicrob Chemother. 2008 Nov;62(5):1156-8. doi: 10.1093/jac/dkn314. Epub 2008 Jul 30. PubMed PMID: 18667449. 5: Villegas-Estrada A, Lee M, Hesek D, Vakulenko SB, Mobashery S. Co-opting the cell wall in fighting methicillin-resistant Staphylococcus aureus: potent inhibition of PBP 2a by two anti-MRSA beta-lactam antibiotics. J Am Chem Soc. 2008 Jul 23;130(29):9212-3. doi: 10.1021/ja8029448. Epub 2008 Jun 27. PubMed PMID: 18582062; PubMed Central PMCID: PMC2747592. 6: Sader HS, Fritsche TR, Jones RN. Antimicrobial activities of Ceftaroline and ME1036 tested against clinical strains of community-acquired methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2008 Mar;52(3):1153-5. doi: 10.1128/AAC.01351-07. Epub 2008 Jan 7. PubMed PMID: 18180353; PubMed Central PMCID: PMC2258508. 7: Dalziel C, Turner B. Interscience conference on antimicrobial agents and chemotherapy--46th annual meeting. Release of data for Dc-159a, and other agents. 27-30 September 2006, San Francisco, CA, USA. IDrugs. 2006 Nov;9(11):765-7. PubMed PMID: 17096295. 8: Nagura J, Kijima K, Kurazono M, Takahata S, Sugano T, Tanaka Y, Hirai Y, Yamada K, Takayama Y, Shitara E, Yonezawa M. Therapeutic effect of ME1036 on endocarditis experimentally induced by methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2005 Aug;49(8):3526-8. PubMed PMID: 16048975; PubMed Central PMCID: PMC1196270. 9: Maeda K, Ida T, Sanbongi Y, Suzuki T, Fukushima T, Kurazono M, Yonezawa M, Ubukata K, Inoue M. Comparison of activities of beta-lactam antibiotics against Streptococcus pneumoniae with recombinant penicillin-binding protein genes from a penicillin-resistant strain. J Infect Chemother. 2005 Apr;11(2):107-11. PubMed PMID: 15856382. 10: Kurazono M, Ida T, Yamada K, Hirai Y, Maruyama T, Shitara E, Yonezawa M. In vitro activities of ME1036 (CP5609), a novel parenteral carbapenem, against methicillin-resistant staphylococci. Antimicrob Agents Chemother. 2004 Aug;48(8):2831-7. PubMed PMID: 15273088; PubMed Central PMCID: PMC478537. 11: Bert F. [Risk factors and treatment of methicillin-resistant Staphylococcus aureus infections]. Presse Med. 2002 Nov 30;31(38):1792-6. Review. French. PubMed PMID: 12497719.

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